Depth-resolved monitoring of glucose diffusion in tissues by using optical coherence tomography

被引：64
|
作者：
Ghosn, Mohamad G.
Tuchin, Valery V.
Larin, Kirill V.
机构：
[1] Univ Houston, Biomed Engn Program, Houston, TX 77204 USA
[2] Saratov NG Chernyshevskii State Univ, Inst Opt & Biophoton, Saratov 410012, Russia
来源：
OPTICS LETTERS | 2006年 / 31卷 / 15期
关键词：
D O I：
10.1364/OL.31.002314
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
We demonstrate the capability of the optical coherence tomography (OCT) technique for depth-resolved monitoring and quantifying of glucose diffusion in fibrous tissues (sclera). The depth-resolved and average permeability coefficients of glucose were calculated. We found that the glucose diffusion rate is not uniform throughout the tissue and is increased from approximately 2.39 +/- 0.73 X 10(-6) cm/s at the epithelial side to 8.63 +/- 0.27 X 10(-6) cm/s close to the endothelial side of the sclera. Results demonstrated that the OCT technique is capable of depth-resolved monitoring and quantification of glucose diffusion in sclera with a resolution of approximately 40 mu m. (c) 2006 Optical Society of America.
引用
收藏
页码：2314 / 2316
页数：3
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