Depth-resolved microscopy of cortical hemodynamics with optical coherence tomography

被引：28
|
作者：
Srinivasan, Vivek J. [1 ]
Sakadzic, Sava [1 ]
Gorczynska, Iwona [2 ,3 ]
Ruvinskaya, Svetlana [1 ]
Wu, Weicheng [1 ]
Fujimoto, James G. [2 ,3 ]
Boas, David A. [1 ]
机构：
[1] Harvard Univ, Massachusetts Gen Hosp, MGH MIT HMS Athinoula A Martinos Ctr Biomed Imagi, Sch Med,Photon Migrat Imaging Lab, Charlestown, MA 02129 USA
[2] MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA
[3] MIT, Elect Res Lab, Cambridge, MA 02139 USA
来源：
OPTICS LETTERS | 2009年 / 34卷 / 20期
基金：
美国国家卫生研究院;
关键词：
IN-VIVO; NEURONAL-ACTIVITY; VISUALIZATION; CORTEX;
D O I：
10.1364/OL.34.003086
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
We describe depth-resolved microscopy of cortical hemodynamics with high-speed spectral/Fourier domain optical coherence tomography (OCT). Stimulus-evoked changes in blood vessel diameter, flow, and total hemoglobin were measured in the rat somatosensory cortex. The results show OCT measurements of hemodynamic changes during functional activation and represent an important step toward understanding functional hyperemia at the microscopic level. (C) 2009 Optical Society of America
引用
收藏
页码：3086 / 3088
页数：3
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