Baker's yeast catalyzed asymmetric reduction in glycerol

被引：75
|
作者：
Wolfson, Adi [1 ]
Dlugy, Christina [1 ]
Tavor, Dorith [1 ]
Blumenfeld, Janine [1 ]
Shotland, Yoram [1 ]
机构：
[1] Sami Shamoon Coll Engn, Green Proc Ctr, Dept Chem Engn, IL-84100 Beer Sheva, Israel
来源：
TETRAHEDRON-ASYMMETRY | 2006年 / 17卷 / 14期
关键词：
D O I：
10.1016/j.tetasy.2006.07.026
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Free and immobilized baker's yeast were successfully employed in the asymmetric hydrogenations of prochiral beta-keto esters and ketones in glycerol. The activities with immobilized cells were always higher then with free cells while the enantio selectivity was very high (99%) with both catalysts. Using glycerol, a non-toxic, biodegradable and recyclable liquid, as an environmentally friendly solvent allowed easy separation of the product by simple extraction with diethyl ether. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2043 / 2045
页数：3
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