Evaluation of GeneXpert MTB/RIF as a diagnostic tool in patients with sputum smear-negative TB in a high HIV burden region in Nigeria

被引:4
|
作者
Tiamiyu, Abdulwasiu Bolaji [1 ]
Iliyasu, Garba [2 ]
Dayyab, Farouq Muhammad [1 ]
Habib, Zaiyad Garba [1 ]
Tambuwal, Sirajo Haliru [1 ]
Galadanci, Habibu [3 ]
Bwala, Sunday A. [3 ]
Lawson, Lovett [4 ]
Habib, Abdulrazaq Garba [2 ]
机构
[1] Aminu Kano Teaching Hosp, Dept Med, Infect & Trop Dis Unit, Kano, Nigeria
[2] Bayero Univ, Coll Hlth Sci, Dept Med, Infect & Trop Dis Unit, Kano, Nigeria
[3] Natl Hosp, Dept Med, Abuja, Nigeria
[4] Zankli Med Ctr, Abuja, Nigeria
关键词
Smear Negative Pulmonary Tuberculosis; HIV Infection; Gene Xpert; Sputum culture; Nigeria; TUBERCULOSIS; RESISTANCE; INFECTION; ASSAY;
D O I
10.1093/trstmh/traa019
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Background There are challenges in the diagnosis of TB in people with smear-negative pulmonary TB (SNPTB) in resource-Limited settings. We evaluated the diagnostic usefulness of Xpert MTB/RIF compared with TB culture among SNPTB. Methods The study was a cross-sectional study among patients with SNPTB. The Xpert MTB/RIF tests and sputum culture (using Lowenstein-Jensen medium) were performed. Sensitivity and specificity were calculated. Results Of 150 patients studied, the sensitivity and specificity of GeneXpert MTB/RIF were 81.8 and 97.4%, respectively. Conclusion The sensitivity and specificity of Xpert MTB/RIF assay was comparative with culture in SNPTB patients.
引用
收藏
页码:697 / 699
页数:3
相关论文
共 50 条
  • [21] GENEXPERT MTB.RIF ASSAY IMPROVES THE DIAGNOSTIC YIELD OF EBUS-TBNA IN SMEAR-NEGATIVE INTRA-THORACIC TUBERCULOUS LYMPHADENOPATHY
    Dhasmana, D. J.
    Bradley, C. J.
    George, P.
    Connell, D. W.
    Molyneaux, P.
    Singanayagam, A.
    Lalvani, A.
    Jepson, A.
    Kon, O. M.
    Cooke, G. S.
    THORAX, 2011, 66 : A75 - A75
  • [22] Evaluation of a Diagnostic Algorithm for Sputum Smear-Negative Pulmonary Tuberculosis in HIV-Infected Adults
    Padmapriyadarsini, Chandrasekaran
    Tripathy, Srikanth
    Sekar, Lakshmanan
    Bhavani, Perumal Kannabiran
    Gaikwad, Nitin
    Annadurai, Srinivasan
    Narendran, Gopalan
    Selvakumar, Nagamiah
    Risbud, Arun R.
    Sheta, Dinesh
    Rajasekaran, Sikhamani
    Thomas, Aleyamma
    Wares, Fraser
    Swaminathan, Soumya
    JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2013, 63 (03) : 331 - 338
  • [23] Evaluation of the use of GeneXpert MTB/RIF in a zone with high burden of tuberculosis in Thailand
    Pongpeeradech, Nathakorn
    Kasetchareo, Yuthichai
    Chuchottaworn, Charoen
    Lawpoolsri, Saranath
    Silachamroon, Udomsak
    Kaewkungwal, Jaranit
    PLOS ONE, 2022, 17 (07):
  • [24] The Diagnostic Accuracy of Urine-Based Xpert MTB/RIF in HIV-Infected Hospitalized Patients Who Are Smear-Negative or Aputum Scarce
    Peter, Jonathan G.
    Theron, Grant
    Muchinga, Tapuwa E.
    Govender, Ureshnie
    Dheda, Keertan
    PLOS ONE, 2012, 7 (07):
  • [25] Evaluation of the Xpert MTB/RIF assay for the diagnosis of smear-negative pulmonary and extrapulmonary tuberculosis in Madagascar
    Rakotoarivelo, R.
    Ambrosioni, J.
    Rasolofo, V.
    Raberahona, M.
    Rakotosamimanana, N.
    Andrianasolo, R.
    Ramanampamonjy, R.
    Tiaray, M.
    Razafimahefa, J.
    Rakotoson, J.
    Randria, M.
    Bonnet, F.
    Calmy, A.
    INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2018, 69 : 20 - 25
  • [27] Evaluation of the culture-enhanced Xpert MTB/RIF assay for the diagnosis of smear-negative tuberculosis
    Noussair, Latifa
    Bert, Frederic
    Leflon-Guibout, Veronique
    Metivier, Roselyne
    Chauvet, Chantal
    Napol, Catherine
    Nicolas-Chanoine, Marie-Helene
    MEDECINE ET MALADIES INFECTIEUSES, 2019, 49 (06): : 467 - 470
  • [28] Xpert® MTB/RIF associated with improved treatment initiation among patients with smear-negative tuberculosis
    Zawedde-Muyanja, S.
    Manabe, Y. C.
    Sewankambo, N. K.
    Nakiyingi, L.
    Nakanjako, D.
    INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 2018, 22 (12) : 1475 - +
  • [29] Evaluation of GeneXpert MTB/RIF assay as a potential diagnostic tool of Mycobacterium tuberculosis (MTB) in Chittagong metropolitan city
    Tumpa, Nasrin Jahan Salma
    Chowdhury, Dil Umme Salma
    Ahmed, Md. Shakeel
    Islam, Nazneen Naher
    MALAYSIAN JOURNAL OF MICROBIOLOGY, 2024, 20 (04) : 445 - 450
  • [30] Bronchoalveolar Lavage Genexpert Mtb/rif® Performance In Smear-Negative Pulmonary Tuberculosis A Tertiary Care Experience In Rio De Janeiro, Brazil
    Mafort, T. T.
    Rodrigues, L. S.
    Santos, A.
    Reis, L. V. T.
    Faria, L. F.
    Brito, G. M. X.
    Leung, J. M.
    Pinto, B. M.
    Rufino, R.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2017, 195