Evaluation of GeneXpert MTB/RIF as a diagnostic tool in patients with sputum smear-negative TB in a high HIV burden region in Nigeria

被引：4
|
作者：
Tiamiyu, Abdulwasiu Bolaji [1 ]
Iliyasu, Garba [2 ]
Dayyab, Farouq Muhammad [1 ]
Habib, Zaiyad Garba [1 ]
Tambuwal, Sirajo Haliru [1 ]
Galadanci, Habibu [3 ]
Bwala, Sunday A. [3 ]
Lawson, Lovett [4 ]
Habib, Abdulrazaq Garba [2 ]
机构：
[1] Aminu Kano Teaching Hosp, Dept Med, Infect & Trop Dis Unit, Kano, Nigeria
[2] Bayero Univ, Coll Hlth Sci, Dept Med, Infect & Trop Dis Unit, Kano, Nigeria
[3] Natl Hosp, Dept Med, Abuja, Nigeria
[4] Zankli Med Ctr, Abuja, Nigeria
来源：
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 2020年 / 114卷 / 09期
关键词：
Smear Negative Pulmonary Tuberculosis; HIV Infection; Gene Xpert; Sputum culture; Nigeria; TUBERCULOSIS; RESISTANCE; INFECTION; ASSAY;
D O I：
10.1093/trstmh/traa019
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Background There are challenges in the diagnosis of TB in people with smear-negative pulmonary TB (SNPTB) in resource-Limited settings. We evaluated the diagnostic usefulness of Xpert MTB/RIF compared with TB culture among SNPTB. Methods The study was a cross-sectional study among patients with SNPTB. The Xpert MTB/RIF tests and sputum culture (using Lowenstein-Jensen medium) were performed. Sensitivity and specificity were calculated. Results Of 150 patients studied, the sensitivity and specificity of GeneXpert MTB/RIF were 81.8 and 97.4%, respectively. Conclusion The sensitivity and specificity of Xpert MTB/RIF assay was comparative with culture in SNPTB patients.
引用
收藏
页码：697 / 699
页数：3
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