Effects of isothiocyanates on tumor necrosis factor-α production by J774A.1 (BALB/c macrophage) cells

被引：3
|
作者：
Ohta, Y [1 ]
Yamaki, K
Osawa, T
Kawakishi, S
机构：
[1] Hiroshima Prefectural Food Technol Res Ctr, Minami Ku, Hiroshima 7320816, Japan
[2] Natl Agr Res Ctr Tohoku Reg, Fukushima 9602156, Japan
[3] Nagoya Univ, Grad Sch Bioagr Sci, Chikusa Ku, Nagoya, Aichi 4648601, Japan
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2004年 / 68卷 / 06期
关键词：
isothiocyanate; tumor necrosis factor-alpha; macrophage; priming effect; inhibitory effect;
D O I：
10.1271/bbb.68.1375
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The effects of isothiocyanates (ITCs) on tumor necrosis factor-alpha (TNF-alpha) production by the J774A.1 mouse macrophage cell line stimulated with lipopolysaccharide (LPS) were examined. Some individual ITCs examined showed a priming effect, which was expressed as pre-activation, but also inhibited the production of TNF-a with concomitant stimulation by LPS, as a triggering stimulant of TNF production. These results suggest that ITCs exert opposing activities that can enhance or inhibit the host defense system.
引用
收藏
页码：1375 / 1378
页数：4
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