Neonatal Cutaneous Invasive Aspergillosis Accompanied by Hemophagocytic Lymphohistocytosis

被引：0

作者：

Chen, Zhuanggui ^{[1
]}

Yang, Lifen ^{[1
]}

Li, Yating ^{[1
]}

Pan, Li ^{[1
]}

Li, Meirong ^{[2
]}

Al-Hatmi, Abdullah M. S. ^{[3
,4
,5
]}

Meis, Jacques F. ^{[6
,7
]}

Lai, Wei ^{[2
]}

Feng, Peiying ^{[2
]}

机构：

[1] Sun Yat Sen Univ, Dept Pediat, Affiliated Hosp 3, Guangzhou, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Dermatol, Guangzhou, Guangdong, Peoples R China

[3] Univ Amsterdam, Inst Biodivers & Ecosyst Dynam, Amsterdam, Netherlands

[4] CBS KNAW Fungal Biodivers Ctr, Utrecht, Netherlands

[5] Ibri Hosp, Minist Hlth, Directorate Gen Hlth Serv, Ibri, Oman

[6] Radboud Univ Nijmegen, Med Ctr, Dept Med Microbiol, Nijmegen, Netherlands

[7] Canisius Wilhelmina Hosp, Dept Med Microbiol & Infect Dis, Nijmegen, Netherlands

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2017年 / 36卷 / 04期

关键词：

neonate; cutaneous aspergillosis; Aspergillus flavus; hemophagocytic lymphohistocytosis; posaconazole; LYMPHOHISTIOCYTOSIS; MANAGEMENT; DIAGNOSIS; MULTICENTER; UPDATE;

D O I：

10.1097/INF.0000000000001463

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We describe a 6-week-old female infant with cutaneous invasive aspergillosis accompanied with hemophagocytic lymphohistocytosis. Aspergillus flavus was isolated from biopsies of necrotic skin lesions on the forehead and scalp; morphologic identification was confirmed by molecular analysis. In vitro antifungal susceptibility testing showed that amphotericin B and triazoles had potent activity. The patient responded well to treatment with intravenous amphotericin B combined with oral posaconazole and local wound care. The hemophagocytic lymphohistocytosis abated after treatment of cutaneous aspergillosis. Both cutaneous invasive aspergillosis and hemophagocytic lymphohistocytosis are severe disorders with high morbidity and mortality requiring prompt diagnosis and treatment.

引用

页码：423 / 425

页数：3

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