The Molecular Machinery of Neurotransmitter Release (Nobel Lecture)

被引：123
|
作者：
Suedhof, Thomas C. [1 ,2 ]
机构：
[1] Stanford Univ, Sch Med, Dept Mol & Cellular Physiol, Stanford, CA 94305 USA
[2] Stanford Univ, Sch Med, Howard Hughes Med Inst, Stanford, CA 94305 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2014年 / 53卷 / 47期
关键词：
hormone secretion; membrane fusion; intracellular signaling; synaptic plasticity; vesicular transport; SYNAPTIC VESICLE PROTEIN; INTRACELLULAR CALCIUM-DEPENDENCE; PRESYNAPTIC ACTIVE ZONES; NEURONAL SNARE COMPLEX; TRANSMITTER RELEASE; MEMBRANE-FUSION; SYNAPTOTAGMIN-I; CA2+ SENSOR; BINDING PROTEIN; 3-DIMENSIONAL STRUCTURE;
D O I：
10.1002/anie.201406359
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The most important property of synaptic transmission is its speed, which is crucial for the overall workings of the brain. In his Nobel Lecture, T. C. Südhof explains how the synaptic vesicle and the plasma membrane undergo rapid fusion during neurotransmitter release and how this process is spatially organized, such that opening of Ca2+-channels allows rapid translation of the entering Ca2+ signal into a fusion event. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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页码：12696 / 12717
页数：22
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