Ruthenium(II)-Catalyzed meta C-H Mono- and Difluoromethylations by Phosphine/Carboxylate Cooperation

被引：160
|
作者：
Ruan, Zhixiong [1 ]
Zhang, Shou-Kun [1 ]
Zhu, Cuiju [1 ]
Ruth, Paul Niklas [2 ]
Stalke, Dietmar [2 ]
Ackermann, Lutz [1 ]
机构：
[1] Georg August Univ Gottingen, Inst Organ & Biomol Chem, Tammannstr 2, D-37077 Gottingen, Germany
[2] Georg August Univ Gottingen, Inst Anorgan Chem, Tammannstr 4, D-37077 Gottingen, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2017年 / 56卷 / 08期
基金：
欧洲研究理事会;
关键词：
C-H activation; fluorine; meta-selectivity; phosphine; ruthenium; CATALYZED DIRECT ARYLATIONS; BOND ACTIVATION; RECENT PROGRESS; FUNCTIONALIZATION; LIGAND; ARENES; ARYL; OLEFINATION; ALKYLATION; ALKENES;
D O I：
10.1002/anie.201611595
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Ruthenium(II)-catalyzed meta-selective C-H (di) fluoromethylation was accomplished by phosphine and carboxylate cooperation. The remote C-H functionalization was characterized by ample substrate scope, thereby setting the stage for meta-(di) fluoromethylation through facile C-H cleavage.
引用
收藏
页码：2045 / 2049
页数：5
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