Synthesis and Antimicrobial Activities of Novel Quinazolinone Acylhydrazone Derivatives Containing the Indole Moiety

被引：24
|
作者：
Li, Xiao-Qin [1 ]
Gan, Yi-Yuan [2 ]
Meng, Jiao [2 ]
Li, Wen [2 ]
Chen, Jie [2 ]
Qi, Ya-Yun [2 ]
Tian, Kun [1 ]
Ouyang, Gui-Ping [1 ,2 ,3 ]
Wang, Zhen-Chao [2 ,3 ]
机构：
[1] Guizhou Univ, State Key Lab Breeding Base Green Pesticide & Agr, Key Lab Green Pesticide & Agr Bioengn, Minist Educ, Guiyang 550025, Guizhou, Peoples R China
[2] Guizhou Univ, Coll Pharm, Guiyang 550025, Guizhou, Peoples R China
[3] Drug Synthet Engn Lab Guizhou Prov, Guiyang 550025, Guizhou, Peoples R China
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2018年 / 55卷 / 06期
关键词：
TOBACCO BACTERIAL WILT; ANTIBACTERIAL ACTIVITY; HYDRAZONE DERIVATIVES; BIOLOGICAL-ACTIVITIES; DESIGN; ACID; NUCLEOSIDES; INHIBITORS; AGONISTS; CANKER;
D O I：
10.1002/jhet.3172
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of novel quinazolinone acylhydrazone derivatives containing the indole moiety were designed, synthesized, and evaluated for their inhibition activities against some important phytopathogens in vitro. Antibacterial experiments indicated that some compounds exhibited remarkable inhibition activities against tested bacteria. Especially, the EC50 values of 7a (EC50=55.13g/mL against Xoo, EC50=56.92g/mL against Rs) demonstrated the best antibacterial activities against Xoo and Rs than the other compounds, and the control agents Bismerthiazol (EC50=89.80g/mL against Xoo) and Thiodiazole copper (EC50=189.52g/mL against Rs), moreover, compound 7o (EC50=50.80g/mL) displayed the excellent activity against Xac than the control Bismerthiazol (EC50=56.92g/mL).
引用
收藏
页码：1382 / 1390
页数：9
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