Lipid metabolism and transport define longevity of the yeast Saccharomyces cerevisiae

被引：8
|
作者：
Mitrofanova, Darya [1 ]
Dakik, Pamela [1 ]
McAuley, Melissa [1 ]
Medkour, Younes [1 ]
Mohammad, Karamat [1 ]
Titorenko, Vladimir, I [1 ]
机构：
[1] Concordia Univ, Dept Biol, 7141 Sherbrooke St West,Sci Pavil,Off SP-501-13, Montreal, PQ H4B 1R6, Canada
来源：
FRONTIERS IN BIOSCIENCE-LANDMARK | 2018年 / 23卷
基金：
加拿大自然科学与工程研究理事会;
关键词：
Aging; Longevity; Mechanisms; Lipid metabolism; Review; CHRONOLOGICAL LIFE-SPAN; PHOSPHOSPHINGOLIPID PHOSPHOLIPASE-C; DROPLET-ORGANELLE INTERACTIONS; OXIDATIVE STRESS SENSITIVITY; PLANT DEFENSIN-SENSITIVITY; FATTY-ACID-METABOLISM; CALORIC RESTRICTION; MITOCHONDRIAL DYSFUNCTION; SPHINGOLIPID METABOLISM; ENDOPLASMIC-RETICULUM;
D O I：
10.2741/4638
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Emergent evidence indicates that certain aspects of lipid synthesis, degradation and interorganellar transport play essential roles in modulating the pace of cellular aging in the budding yeast Saccharomyces cerevisiae. The molecular mechanisms underlying the vital roles of lipid metabolism and transport in defining yeast longevity have begun to emerge. The scope of this review is to critically analyze recent progress in understanding such mechanisms.
引用
收藏
页码：1166 / 1194
页数：29
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