Maternal and Fetal Outcomes in Pregnancies Complicated by Intrahepatic Cholestasis

Objective: This study aimed to report the maternal and fetal outcomes in women with intrahepatic cholestasis of pregnancy (ICP). Materials and Methods: The maternal and fetal outcomes in 70 consecutive women who gave birth at Ataturk University Hospital between January 2012 and December 2017 were assessed. The clinical diagnosis of ICP and diagnosis confirmed post-delivery when all the symptoms regressed and laboratory parameters returned to normal was utilized. Results: Liver transaminases were elevated in 61 (87%) women. The median week of delivery was 37 (range, 26-42) and the preterm delivery rate was 40% (28 women delivered spontaneously at <= 36 weeks of gestation). Preeclampsia was noted in 8 (11%) women. There were no cases of stillbirth or neonatal death. Conclusion: The rate of stillbirth does not increase in women with ICP. However, further investigations are needed to determine if this result is related to preterm birth.