Biochemical study of human PRMT5 and its structure-based designer small molecule inhibitors for potential cancer therapeutics

被引：0
|
作者：
Zhou, Wei [1 ]
Yang, Xiaozhi [1 ]
Li, Chenglong [1 ]
机构：
[1] Univ Florida, Gainesville, FL USA
来源：
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2019年 / 257卷
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
70
引用
收藏
页数：1
相关论文
共 50 条
  • [41] Identification of small-molecule inhibitors against SecA by structure-based virtual ligand screening
    Evelien De Waelheyns
    Kenneth Segers
    Marios Frantzeskos Sardis
    Jozef Anné
    Gerry A F Nicolaes
    Anastassios Economou
    The Journal of Antibiotics, 2015, 68 : 666 - 673
  • [42] Discovery of small molecule inhibitors of integrin αvβ3 through structure-based virtual screening
    Zhou, Yuan
    Peng, Hui
    Ji, Qing
    Qi, Jing
    Zhu, Zhenping
    Yang, Chunzheng
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (22) : 5878 - 5882
  • [43] Structure-based design of dual AChE and BACE-1 inhibitors as potential therapeutics for neurodegenerative diseases
    Gabr, Moustafa
    Abdel-Raziq, Mohammed
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2019, 258
  • [44] Identification of small-molecule inhibitors against SecA by structure-based virtual ligand screening
    De Waelheyns, Evelien
    Segers, Kenneth
    Sardis, Marios Frantzeskos
    Anne, Jozef
    Nicolaes, Gerry A. F.
    Economou, Anastassios
    JOURNAL OF ANTIBIOTICS, 2015, 68 (11): : 666 - 673
  • [45] Targeting survivin for cancer therapy: Strategies, small molecule inhibitors and vaccine based therapeutics in development
    Kondapuram, Sree Karani
    Ramachandran, Hema Kasthuri
    Arya, Hemant
    Coumar, Mohane Selvaraj
    LIFE SCIENCES, 2023, 335
  • [46] Structure-based design of MRTX1719: an M TA-cooperative PRMT5 Inhibitor for treatment of MTAP-deleted cancers
    Gunn, Robin
    ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 2022, 78 : A224 - A224
  • [47] Ligand and Structure-Based Pharmacophore Modeling for the Discovery of Potential Human HNMT Inhibitors
    Elumalai, Pavadai
    Liu, Hsuan-Liang
    Zhou, Zheng-Li
    Zhao, Jian-Hua
    Chen, Wilson
    Chuang, Chih-Kuang
    Tsai, Wei-Bor
    Ho, Yih
    LETTERS IN DRUG DESIGN & DISCOVERY, 2012, 9 (01) : 17 - 29
  • [48] In Silico Study Probes Potential Inhibitors of Human Dihydrofolate Reductase for Cancer Therapeutics
    Rana, Rabia Mukhtar
    Rampogu, Shailima
    Zeb, Amir
    Son, Minky
    Park, Chanin
    Lee, Gihwan
    Yoon, Sanghwa
    Baek, Ayoung
    Parameswaran, Sarvanan
    Park, Seok Ju
    Lee, Keun Woo
    JOURNAL OF CLINICAL MEDICINE, 2019, 8 (02):
  • [49] Structure-Based Screen Identifies a Potent Small Molecule Inhibitor of Stat5a/b with Therapeutic Potential for Prostate Cancer and Chronic Myeloid Leukemia
    Liao, Zhiyong
    Gu, Lei
    Vergalli, Jenny
    Mariani, Samanta A.
    De Dominici, Marco
    Lokareddy, Ravi K.
    Dagvadorj, Ayush
    Purushottamachar, Puranik
    McCue, Peter A.
    Trabulsi, Edouard
    Lallas, Costas D.
    Gupta, Shilpa
    Ellsworth, Elyse
    Blackmon, Shauna
    Ertel, Adam
    Fortina, Paolo
    Leiby, Benjamin
    Xia, Guanjun
    Rui, Hallgeir
    Hoang, David T.
    Gomella, Leonard G.
    Cingolani, Gino
    Njar, Vincent
    Pattabiraman, Nagarajan
    Calabretta, Bruno
    Nevalainen, Marja T.
    MOLECULAR CANCER THERAPEUTICS, 2015, 14 (08) : 1777 - 1793
  • [50] Structure-Based Optimization of Bisphosphonate Nucleoside Inhibitors of Human 5(3)-deoxyribonucleotidases
    Pachl, Petr
    Simak, Ondrej
    Budesinsky, Milos
    Brynda, Jiri
    Rosenberg, Ivan
    Rezacova, Pavlina
    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2018, 2018 (37) : 5144 - 5153
12345