Dose-response effects of intermittent PTH on cancellous bone in hindlimb unloaded rats

被引：37
|
作者：
Turner, Russell T. [1 ]
Evans, Glenda L.
Lotinun, Sutada
Lapke, Paul D.
Iwaniec, Urszula T.
Morey-Holton, Emily
机构：
[1] Oregon State Univ, Dept Nutr & Exercise Sci, Corvallis, OR 97331 USA
[2] Mayo Clin & Mayo Grad Sch Med, Dept Orthoped, Rochester, MN USA
[3] NASA, Ames Res Ctr, Moffett Field, CA 94035 USA
来源：
JOURNAL OF BONE AND MINERAL RESEARCH | 2007年 / 22卷 / 01期
关键词：
spaceflight; bone formation; bone matrix proteins; histomorphometry; osteoblasts; mu CT;
D O I：
10.1359/JBMR.061006
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
HLU suppressed bone formation and resulted in bone loss in the tibial metaphysis of 6-month-old male rats. A human therapeutic dose of intermittent PTH (I mu g/kg/day) prevented the skeletal changes associated with HLU.
引用
收藏
页码：64 / 71
页数：8
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