Mussel-Inspired Catechol-Functionalized Hydrogels and Their Medical Applications

被引：71
|
作者：
Quan, Wei-Yan [1 ]
Hu, Zhang [1 ]
Liu, Hua-Zhong [1 ]
Ouyang, Qian-Qian [1 ]
Zhang, Dong-Ying [1 ]
Li, Si-Dong [1 ]
Li, Pu-Wang [2 ]
Yang, Zi-Ming [2 ]
机构：
[1] Guangdong Ocean Univ, Dept Appl Chem, Sch Chem & Environm Sci, Zhanjiang 524088, Peoples R China
[2] Chinese Acad Trop Agr Sci, Key Lab Trop Crop Prod Proc, Minist Agr & Rural Affairs, Agr Prod Proc Res Inst, Zhanjiang 524001, Peoples R China
来源：
MOLECULES | 2019年 / 24卷 / 14期
关键词：
mussel adhesive protein; catechol; hydrogel; medical application; IN-VITRO CHARACTERIZATION; MODIFIED HYALURONIC-ACID; DRUG-DELIVERY SYSTEM; HIGH WET STRENGTH; MARINE-MUSSEL; ADHESIVE PROTEIN; TISSUE ADHESIVE; CROSS-LINKING; NANOCOMPOSITE HYDROGEL; ANTIMICROBIAL ACTIVITY;
D O I：
10.3390/molecules24142586
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mussel adhesive proteins (MAPs) have a unique ability to firmly adhere to different surfaces in aqueous environments via the special amino acid, 3,4-dihydroxyphenylalanine (DOPA). The catechol groups in DOPA are a key group for adhesive proteins, which is highly informative for the biomedical domain. By simulating MAPs, medical products can be developed for tissue adhesion, drug delivery, and wound healing. Hydrogel is a common formulation that is highly adaptable to numerous medical applications. Based on a discussion of the adhesion mechanism of MAPs, this paper reviews the formation and adhesion mechanism of catechol-functionalized hydrogels, types of hydrogels and main factors affecting adhesion, and medical applications of hydrogels, and future the development of catechol-functionalized hydrogels.
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页数：27
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