Despite several studies suggesting the effectiveness of traditional Chinese medicine (TCM) in schizophrenia, there is still a lack of systematic summary and analysis on the role of TCM as adjuvant therapy in chronic schizophrenia. For this purpose, we conducted a meta-analysis to study the efficacy of TCM as an adjuvant combined with antipsychotics in the treatment of chronic schizophrenia. Until April 2020, based on the review of six electronic databases, eight articles were selected. The articles compared TCM decoction assisted antipsychotic therapies with an antipsychotic alone in the treatment of chronic schizophrenia by analyzing a total of 810 cases. The results showed that TCM combined with antipsychotics have beneficial effects on the Positive and Negative Syndrome Scale (PANSS), including the changes in total score, negative score, and the clinical effects evaluated by the PANSS scale. Subgroup analysis showed that the effects of auxiliary TCM with different efficacy on the positive and psychopathological scores were significantly different. It was found that adjuvant treatment with TCM can reduce some side effects and improve the patient's living conditions in the evaluation of the Schizophrenia Quality Of Life Scale (SQLS). Many studies have proved that TCM is safe and well-tolerated. Although the difficulties of using limited TCM remains to be generalized, it still has great potential in the adjuvant treatment of chronic schizophrenia.
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Hong Kong Polytech Univ, Dept Rehabil Sci, Hong Kong, Peoples R China
Hong Kong Polytech Univ, Mental Hlth Res Ctr, Hong Kong, Peoples R ChinaASST Spedali Civili, Dept Mental Hlth & Addict Serv, Brescia, Italy
机构:
Changchun Univ Chinese Med, Dept Tradit Chinese Med, Changchun, Jilin, Peoples R ChinaChangchun Univ Chinese Med, Dept Tradit Chinese Med, Changchun, Jilin, Peoples R China
Wang, Zhilei
Zhang, Shoulin
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Changchun Univ Chinese Med, Dept Nephrol, Jilin Prov Hosp Chinese Med, Affiliated Hosp 1, 1478 Gongnong Rd, Changchun 13001Z, Jilin, Peoples R ChinaChangchun Univ Chinese Med, Dept Tradit Chinese Med, Changchun, Jilin, Peoples R China
Zhang, Shoulin
Zheng, Xue
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Changchun Univ Chinese Med, Dept Tradit Chinese Med, Changchun, Jilin, Peoples R ChinaChangchun Univ Chinese Med, Dept Tradit Chinese Med, Changchun, Jilin, Peoples R China
Zheng, Xue
Zhang, Lili
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Changchun Univ Chinese Med, Dept Tradit Chinese Med, Changchun, Jilin, Peoples R ChinaChangchun Univ Chinese Med, Dept Tradit Chinese Med, Changchun, Jilin, Peoples R China
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Wuhan Asia Gen Hosp, Dept Tradit Chinese Med, Wuhan 430056, Hubei, Peoples R ChinaWuhan Asia Gen Hosp, Dept Tradit Chinese Med, Wuhan 430056, Hubei, Peoples R China
Zhu, Qiongjie
Xu, Wenjin
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Wuhan Asia Gen Hosp, Dept Tradit Chinese Med, Wuhan 430056, Hubei, Peoples R ChinaWuhan Asia Gen Hosp, Dept Tradit Chinese Med, Wuhan 430056, Hubei, Peoples R China
Xu, Wenjin
Li, Xuesong
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Wuhan Asia Gen Hosp, Dept Tradit Chinese Med, Wuhan 430056, Hubei, Peoples R ChinaWuhan Asia Gen Hosp, Dept Tradit Chinese Med, Wuhan 430056, Hubei, Peoples R China
机构:
Collaborative Innovation Center of Integrated Traditional and Western Medicine for Reproductive Health, The First Affiliated Hospital, Tianjin University of Traditional Chinese MedicineCollaborative Innovation Center of Integrated Traditional and Western Medicine for Reproductive Health, The First Affiliated Hospital, Tianjin University of Traditional Chinese Medicine
Tian Xia
Rui-hong Ma
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Collaborative Innovation Center of Integrated Traditional and Western Medicine for Reproductive Health, The First Affiliated Hospital, Tianjin University of Traditional Chinese MedicineCollaborative Innovation Center of Integrated Traditional and Western Medicine for Reproductive Health, The First Affiliated Hospital, Tianjin University of Traditional Chinese Medicine
Rui-hong Ma
Wei Mu
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Center for Evidence-Based Medicine, Tianjin University of Traditional Chinese MedicineCollaborative Innovation Center of Integrated Traditional and Western Medicine for Reproductive Health, The First Affiliated Hospital, Tianjin University of Traditional Chinese Medicine
Wei Mu
Meng-di Hu
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Collaborative Innovation Center of Integrated Traditional and Western Medicine for Reproductive Health, The First Affiliated Hospital, Tianjin University of Traditional Chinese MedicineCollaborative Innovation Center of Integrated Traditional and Western Medicine for Reproductive Health, The First Affiliated Hospital, Tianjin University of Traditional Chinese Medicine
Meng-di Hu
Sai-hua Ma
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Collaborative Innovation Center of Integrated Traditional and Western Medicine for Reproductive Health, The First Affiliated Hospital, Tianjin University of Traditional Chinese MedicineCollaborative Innovation Center of Integrated Traditional and Western Medicine for Reproductive Health, The First Affiliated Hospital, Tianjin University of Traditional Chinese Medicine
Sai-hua Ma
Shu-wen Mao
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Collaborative Innovation Center of Integrated Traditional and Western Medicine for Reproductive Health, The First Affiliated Hospital, Tianjin University of Traditional Chinese MedicineCollaborative Innovation Center of Integrated Traditional and Western Medicine for Reproductive Health, The First Affiliated Hospital, Tianjin University of Traditional Chinese Medicine
Shu-wen Mao
Yu Fu
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Collaborative Innovation Center of Integrated Traditional and Western Medicine for Reproductive Health, The First Affiliated Hospital, Tianjin University of Traditional Chinese MedicineCollaborative Innovation Center of Integrated Traditional and Western Medicine for Reproductive Health, The First Affiliated Hospital, Tianjin University of Traditional Chinese Medicine