Proteomics-based approach to elucidate the mechanism of antitumor effect of curcumin in cervical cancer

被引：25
|
作者：
Madden, Krystal [1 ]
Flowers, Lisa [3 ]
Salani, Ritu [2 ]
Horowitz, Ira [3 ]
Logan, Sanjay [3 ]
Kowalski, Kevin
Xie, Jun [4 ]
Mohammed, Sulma I. [1 ,5 ]
机构：
[1] Purdue Univ, Dept Comparat Pathobiol, W Lafayette, IN 47907 USA
[2] Emory Univ, Sch Med, Dept Obstet Gynecol, Atlanta, GA USA
[3] Emory Univ, Sch Med, Dept Pathol, Atlanta, GA 30322 USA
[4] Purdue Univ, Dept Stat, W Lafayette, IN 47907 USA
[5] Purdue Univ, Purdue Canc Ctr, W Lafayette, IN 47907 USA
来源：
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 2009年 / 80卷 / 01期
关键词：
Cervical cancer; Curcumin; Cox-2; HUMAN-PAPILLOMAVIRUS; INTERNATIONAL TRENDS; INDUCED EXPRESSION; CYCLOOXYGENASE-2; ADENOCARCINOMA; CARCINOMA; PROMOTION; CELLS; COX-2; OVEREXPRESSION;
D O I：
10.1016/j.plefa.2008.10.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cervical cancer is the second leading cause of cancer death for women in the world. A potential target for preventing and treating cervical cancer is cyclooxygenase-2 (cox-2). Curcumin is an anti-inflammatory agent that is known to have anti-cox-2 activity. In this study we examined the expression of cox-2 in cervical cancer and its precursors by immunohistochemistry. The effect of curcumin in inhibiting cervical cancer cells was determined via 2-dimensional gel electrophoresis, data analysis, and ingenuity pathway analysis. No significant differences in the expression of cox-2 in squamous cell carcinoma, and carcinoma in situ were observed. However, there was a statistically significant difference in the expression of cox-2 in adenocarcinoma in comparison to normal (p value = 0.01) and squamous cell carcinoma (p value = 0.02) tissues. Proteins associated with cancer and cell cycle were significantly altered in cultured cells. Curcumin may have antitumor effect in cervical cancer. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：9 / 18
页数：10
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