SYNTHESIS AND CHARACTERIZATION OF SOME NOVEL AZODERIVATIVES

被引：0

作者：

Rau, Gabriela ^{[1
]}

Mogosanu, George-Dan ^{[2
]}

Stanciulescu, Camelia Elena

机构：

[1] Univ Med & Pharm Craiova, Fac Pharm, Dept Organ Chem & Med Chem, Craiova 200349, Romania

[2] Univ Med & Pharm Craiova, Fac Pharm, Dept Pharmacognosy & Phytotherapy, Craiova 200349, Romania

来源：

FARMACIA | 2009年 / 57卷 / 05期

关键词：

azoderivatives; synthesis;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The paper presents 15 novel azoderivatives, obtained by the condensation of 2-methyl-N-chloroacetylaniline or 2-ethoxy-N-chloroacetylaniline with 4-(phenylazo) phenols 4'-substituted or not, or with 4-hydroxy4'-(phenylazo) biphenyls 4 ''-substituted or not, These new compounds have been characterized using physical methods (UV-Vis, IR, (1)H-NMR and Mass Spectra). The molecular modelling of the chemical structures, concerning molecular descriptors for QSPR (Quantitative Structure Property Relationship), was performed with Hyperchem 6.0, MM+ (Molecular Mechanics) method, CODESSA and MOPAC 6.0 soft packages. The phytobiological activity (Triticum test) was determined for the novel azoderivatives.

引用

页码：648 / 658

页数：11

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