Clinicopathological Variation of Lauren Classification in Gastric Cancer

被引:189
|
作者
Chen, Yun-Chi [1 ,2 ]
Fang, Wen-Liang [1 ,2 ]
Wang, Ruei-Fang [8 ,9 ]
Liu, Chien-An [2 ,6 ]
Yang, Muh-Hwa [3 ,4 ]
Lo, Shu-Shun [2 ,7 ]
Wu, Chew-Wen [1 ,2 ]
Li, Anna Fen-Yau [2 ,5 ]
Shyr, Yi-Ming [1 ,2 ]
Huang, Kuo-Hung [1 ,3 ]
机构
[1] Taipei Vet Gen Hosp, Dept Surg, Div Gen Surg, Taipei 11217, Taiwan
[2] Natl Yang Ming Univ, Sch Med, Taipei 112, Taiwan
[3] Natl Yang Ming Univ, Sch Med, Inst Clin Med, Taipei 112, Taiwan
[4] Taipei Vet Gen Hosp, Dept Med, Div Hematol Oncol, Taipei 11217, Taiwan
[5] Taipei Vet Gen Hosp, Dept Pathol, Taipei 11217, Taiwan
[6] Taipei Vet Gen Hosp, Dept Radiol, Taipei 11217, Taiwan
[7] Natl Yang Ming Univ Hosp, Yilan, Taiwan
[8] Shin Kong Wu Ho Mem Hosp, Dept Emergency Med, Taipei, Taiwan
[9] Fu Jen Catholic Univ, Sch Med, New Taipei, Taiwan
关键词
Gastric cancer; Gastrecotomy; Lauren's classification; PROGNOSTIC-FACTOR; MIXED-TYPE; CARCINOMA; DISSECTION; TRIAL; HER2;
D O I
10.1007/s12253-015-9996-6
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The investigation of prognostic factor for gastric cancer is still desirable because of dismal prognosis in gastric cancer. Lauren's classification is currently a useful histological classification. There are few large series evaluating the prognostic significance of Lauren's classification in gastric cancer. From January 1987 to December 2013, a total of 3071 patients received gastrectomy for gastric cancer. According Lauren's classification, 1423(46.3 %) patients were intestinal type, 1000 patients (32.6 %) were diffuse type, and 648 patients (21.1 %) were mixed type. The clinicopathological characteristics and prognosis in Lauren's classification were analyzed in these patients. Our results showed that patients with intestinal type gastric cancer (57.7 %) had a better 5-year overall survival than diffuse type (45.6 %) and mixed type (43.4 %, P < 0.001). The clinicopathological characteristics showed that gastric cancer patients with intestinal type were older (P < 0.001), male predominant (P < 0.001), smaller tumor size (P < 0.001), distal stomach predominant (P < 0.001), relative well differentiated (P < 0.001), less advanced Borrmann type (P < 0.001), less scirrhous type stromal reaction(P < 0.001), less infiltrating type of Ming's histology type(P < 0.001), less tumor invasion depth and less lymphovascular invasion (P < 0.001). Multivariate analysis with overall survival as an endpoint showed that age (P = 0.005), Borrmann classification (P < 0.001), pathological T category (P = 0.023), pathological N category (P < 0.001) and Lauren's classification (P = 0.003) were significant correlated in gastric cancer. Lauren's classification is an independent prognostic factor in gastric cancer patient undergoing gastrectomy. Lauren's classification can serve as a prognostic marker for gastric cancer patient receiving gastrectomy. The clinicopathological appearance and prognosis of mixed type gastric cancer is similar to diffuse type gastric cancer.
引用
收藏
页码:197 / 202
页数:6
相关论文
共 50 条
  • [41] Clinical Relevance of the Tumor Location-Modified Lauren Classification System for Gastric Cancer in a Western Population
    Moore, J. L.
    Davies, A. R.
    Santaolalla, A.
    Van Hemelrijck, M.
    Maisey, N.
    Lagergren, J.
    Gossage, J. A.
    Kelly, M.
    Baker, C. R.
    ANNALS OF SURGICAL ONCOLOGY, 2022, 29 (06) : 3911 - 3920
  • [42] The relationship between HER2 expression and Lauren classification in Chinese gastric cancer patients.
    Xu, Rui-hua
    Oiu, Miao-Zhen
    Zhou, Yi-xin
    Zhang, Xin-ke
    Wang, Fang
    Shao, Jian-Yong
    Jin, Ying
    Wang, Zhiqiang
    Zhang, Sheng Dong
    Wang, Fenghua
    Li, Yu-hong
    JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (15)
  • [43] TO THE PROBLEM OF THE HISTOLOGICAL CLASSIFICATION OF THE GASTRIC-CARCINOMA ACCORDING TO LAUREN AND ACCORDING TO THE CLASSIFICATION OF THE WHO
    BRANDT, W
    ZEITSCHRIFT FUR KLINISCHE MEDIZIN-ZKM, 1986, 41 (15): : 1195 - 1197
  • [44] Treatment of Locally Advanced Gastric Cancer (LAGC): Back to Lauren's Classification in Pan-Cancer Analysis Era?
    Zurlo, Ina Valeria
    Basso, Michele
    Strippoli, Antonia
    Calegari, Maria Alessandra
    Orlandi, Armando
    Cassano, Alessandra
    Di Salvatore, Mariantonietta
    Garufi, Giovanna
    Bria, Emilio
    Tortora, Giampaolo
    Barone, Carlo
    Pozzo, Carmelo
    CANCERS, 2020, 12 (07) : 1 - 11
  • [45] A radiomics nomogram analysis based on CT images and clinical features for preoperative Lauren classification in gastric cancer
    Tingting Nie
    Dan Liu
    Shuangquan Ai
    Yaoyao He
    Miao Yang
    Jun Chen
    Zilong Yuan
    Yulin Liu
    Japanese Journal of Radiology, 2023, 41 : 401 - 408
  • [47] Cytokeratin expression patterns of gastric carcinomas according to Lauren and Goseki classification
    Gurbuz, Yesim
    Kose, Nur
    APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY, 2006, 14 (03): : 303 - 308
  • [48] GASTRIC-CANCER - HISTOPATHOLOGIC PATTERNS ACCORDING TO LAUREN CLASSIFICATION IN A HIGH-RISK AREA AND DISTRIBUTION BY RESIDENCE
    AMADORI, D
    PALLI, D
    PADOVANI, F
    FALCINI, F
    BUIATTI, E
    SARAGONI, A
    RAVAIOLI, A
    TUMORI, 1986, 72 (05) : 481 - 486
  • [49] Lauren classification combined with HER2 status is a better prognostic factor in Chinese gastric cancer patients
    Qiu, Miaozhen
    Zhou, Yixin
    Zhang, Xinke
    Wang, Zixian
    Wang, Fang
    Shao, Jianyong
    Lu, Jiabin
    Jin, Ying
    Wei, Xiaoli
    Zhang, Dongsheng
    Wang, Fenghua
    Li, Yuhong
    Yang, Dajun
    Xu, Ruihua
    BMC CANCER, 2014, 14
  • [50] Differences between biopsy- or specimen-related Lauren and World Health Organization classification in gastric cancer
    Flucke, U
    Mönig, SP
    Baldus, SE
    Zirbes, TK
    Bollschweiler, E
    Thiele, J
    Dienes, HP
    Hölscher, AH
    WORLD JOURNAL OF SURGERY, 2002, 26 (02) : 137 - 140