Maternal and Fetal Metabolites in Gestational Diabetes Mellitus: A Narrative Review

被引：11

作者：

Vladu, Ionela Mihaela ^{[1
]}

Clenciu, Diana ^{[1
]}

Mitrea, Adina ^{[1
]}

Amzolini, Anca ^{[2
]}

Micu, Simona Elena ^{[2
]}

Crisan, Anda Elena ^{[3
]}

Efrem, Ion Cristian ^{[4
]}

Fortofoiu, Maria ^{[5
]}

Fortofoiu, Mircea Catalin ^{[2
]}

Mita, Adrian ^{[2
]}

Barau Alhija, Anca ^{[2
]}

Glodeanu, Adina Dorina ^{[4
]}

Mota, Maria ^{[1
]}

机构：

[1] Univ Med & Pharm Craiova, Dept Diabet Nutr & Metab Dis, Fac Med, Craiova 200349, Romania

[2] Univ Med & Pharm Craiova, Dept Internal Med, Med Semiol, Fac Med, Craiova 200349, Romania

[3] Univ Med & Pharm Craiova, Dept Oncol, Fac Med, Craiova 200349, Romania

[4] Univ Med & Pharm Craiova, Dept Internal Med & Med Semiol, Fac Dent, Craiova 200349, Romania

[5] Univ Med & Pharm Craiova, Dept Emergency Med, Fac Med, Craiova 200349, Romania

来源：

METABOLITES | 2022年 / 12卷 / 05期

关键词：

gestational diabetes mellitus; metabolomics; obesity; cardiovascular risk; biomarkers; metabolic pathways; INSULIN SENSITIVITY; URINARY METABOLOME; SERUM METABOLITES; PREGNANT-WOMEN; FATTY-ACIDS; RISK; RESISTANCE; HYPERGLYCEMIA; DIAGNOSIS; CRITERIA;

D O I：

10.3390/metabo12050383

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gestational diabetes mellitus (GDM) is a major public health issue of our century due to its increasing prevalence, affecting 5% to 20% of all pregnancies. The pathogenesis of GDM has not been completely elucidated to date. Increasing evidence suggests the association of environmental factors with genetic and epigenetic factors in the development of GDM. So far, several metabolomics studies have investigated metabolic disruptions associated with GDM. The aim of this review is to highlight the usefulness of maternal metabolites as diagnosis markers of GDM as well as the importance of both maternal and fetal metabolites as prognosis biomarkers for GDM and GDM's transition to type 2 diabetes mellitus T2DM.

引用

页数：16

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