Biological effects of G1 phase arrest compound, sesquicillin, in human breast cancer cell lines

被引：13

作者：

Jeong, HW

Lee, HJ

Kho, YH

Son, KH

Han, MY

Lim, JS

Lee, MY

Han, DC

Ha, JH

Kwon, BM

机构：

[1] Korea Res Inst Biosci & Biotechnol, Taejon 305600, South Korea

[2] Kyungpook Natl Univ, Dept Genet Engn, Taegu 702701, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2002年 / 10卷 / 10期

关键词：

D O I：

10.1016/S0968-0896(02)00225-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sesquicillin, isolated from fungal fermentation broth, strongly induced G1 phase arrest in human breast cancer cells. During G1 phase arrest, the expression level of cyclin D1, cyclin A, and cyclin E was decreased, and the expression of CDK (cyclin-dependent-kinase) inhibitor, protein p21(Waf1/CiP1), was increased in a time-dependent manner in a breast cancer cell MCF-7. Interestingly, the G1 phase arrest induced by sesquicillin also occurred independently of the tumor suppressor protein, p53. Sesquicillin inhibits the proliferation of MCF-7 via G1 phase arrest in association with the induction of CDK inhibitor protein, p21(waf1/CiP1), and the reduction of G1 phase related-cyclin proteins. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：3129 / 3134

页数：6

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