Biological effects of G1 phase arrest compound, sesquicillin, in human breast cancer cell lines

被引:13
|
作者
Jeong, HW
Lee, HJ
Kho, YH
Son, KH
Han, MY
Lim, JS
Lee, MY
Han, DC
Ha, JH
Kwon, BM
机构
[1] Korea Res Inst Biosci & Biotechnol, Taejon 305600, South Korea
[2] Kyungpook Natl Univ, Dept Genet Engn, Taegu 702701, South Korea
关键词
D O I
10.1016/S0968-0896(02)00225-0
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Sesquicillin, isolated from fungal fermentation broth, strongly induced G1 phase arrest in human breast cancer cells. During G1 phase arrest, the expression level of cyclin D1, cyclin A, and cyclin E was decreased, and the expression of CDK (cyclin-dependent-kinase) inhibitor, protein p21(Waf1/CiP1), was increased in a time-dependent manner in a breast cancer cell MCF-7. Interestingly, the G1 phase arrest induced by sesquicillin also occurred independently of the tumor suppressor protein, p53. Sesquicillin inhibits the proliferation of MCF-7 via G1 phase arrest in association with the induction of CDK inhibitor protein, p21(waf1/CiP1), and the reduction of G1 phase related-cyclin proteins. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:3129 / 3134
页数:6
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