A new approach for the synthesis of N-sulfonyl hydantoins

被引：4

作者：

Rmedi, Hamdi ^{[1
]}

Baklouti, Ahmed ^{[2
]}

机构：

[1] Fac Sci Bizerte, Jarzouna 7021, Tunisia

[2] Univ Tunis El Manor, Lab Struct Organ Chem, Fac Sci Tunis, Tunis 1092, Tunisia

来源：

TETRAHEDRON LETTERS | 2014年 / 55卷 / 26期

关键词：

Sulfonyl isocyanates; alpha-Bromoacetamides; N-Sulfonyl hydantoins; Aryloxy and alkoxysulfonyl imidazolidine-2,4-diones; SOLID-PHASE SYNTHESIS; PHARMACOLOGICAL CHARACTERIZATION; ANTICONVULSANT ACTIVITY; ANTITUMOR EVALUATION; ACID LY354740; DERIVATIVES; INHIBITORS; POTENT; UREAS;

D O I：

10.1016/j.tetlet.2014.04.110

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two methods are described for the synthesis of a new series of hydantoins using the same reagents. The best process is based on the addition of N-aryloxy(alkoxy)sulfonyl isocyanates to an equimolar mixture of bromoamides and triethylamine dissolved in anhydrous acetone. This reaction is violent and provides the urea salts in situ which are transformed into the corresponding substituted hydantoins. (C) 2014 Published by Elsevier Ltd.

引用

页码：3585 / 3587

页数：3

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