cDNA cloning of a rat orthologue of SH2D2A encoding T-cell-specific adaptor protein (TSAd):: expression in T and NK cells

被引：11
|
作者：
Nejad, S
Bryceson, Y
Dissen, E
Sundvold-Gjerstad, V
Naper, C
Rolstad, B
Spurkland, A
Vaage, JT
机构：
[1] Univ Oslo, Inst Basic Med Sci, Dept Anat, N-0317 Oslo, Norway
[2] NIAID, NIH Karolinska Inst Grad Partnership Program, Immunogenet Lab, NIH, Rockville, MD 20852 USA
[3] Rikshosp Univ Hosp, Inst Immunol, N-0027 Oslo, Norway
来源：
IMMUNOGENETICS | 2004年 / 56卷 / 05期
关键词：
signal transduction; adapter molecules; lymphocytes;
D O I：
10.1007/s00251-004-0695-9
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The T-cell-specific adapter protein (TSAd), encoded by the SH2D2A gene, has been implicated in modulation of proximal signaling events as well as in transcriptional regulation in human T cells. We have isolated its rat homologue (rSH2D2A) from an NK cell cDNA library and mapped the corresponding gene to chromosome 2 with a hamster-rat radiation hybrid cell panel. rSH2D2A encodes a 376 amino acid protein (rTSAd) which shows greater homology to mouse than human TSAd. In rats, rTSAd was specifically expressed by NK cells and T cells but not by other leukocytes tested. Similarly, in humans we observed abundant transcripts for TSAd in NK cells and T cells. The data suggest that TSAd may have a regulatory role in cellular activation of T and NK cells.
引用
收藏
页码：338 / 342
页数：5
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