Rab35 GTPase and cancer: Linking membrane trafficking to tumorigenesis

被引：30
|
作者：
Shaughnessy, Ronan [1 ]
Echard, Arnaud [1 ,2 ]
机构：
[1] Inst Pasteur, Cell Biol & Infect Dept, Membrane Traff & Cell Div Lab, 28 Rue Dr Roux, F-75015 Paris, France
[2] CNRS, UMR3691, Paris, France
来源：
TRAFFIC | 2018年 / 19卷 / 04期
关键词：
cancer; cell migration; cell signaling; cytokinesis; membrane trafficking; Rab protein; Rab35; tumorigenesis; GUANINE-NUCLEOTIDE EXCHANGE; MICAL-FAMILY PROTEINS; NEURITE OUTGROWTH; DENN-DOMAIN; SUCCESSFUL CYTOKINESIS; CELL-MIGRATION; F-ACTIN; ENDOCYTOSIS; ENDOSOMES; IDENTIFICATION;
D O I：
10.1111/tra.12546
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Rab35 is a small GTPase that is involved in many cellular processes, including membrane trafficking, cell polarity, lipid homeostasis, immunity, phagocytosis and cytokinesis. Recent studies showed that activating mutations confer Rab35 with oncogenic properties. Conversely, downregulation of Rab35 inverts apico-basal cell polarity and promotes cell migration. Here we review Rab35's known functions in membrane trafficking and signaling, cell division and cell migration in cancer cells and discuss the importance of Rab35-dependent membrane trafficking in cancer progression.
引用
收藏
页码：247 / 252
页数：6
相关论文
共 50 条
  • [21] Rab35 GTPase couples cell division with initiation of epithelial apico-basal polarity.
    Klinkert, K.
    Rocancourt, M.
    Houdusse, A. M.
    Echard, A. F.
    MOLECULAR BIOLOGY OF THE CELL, 2015, 26
  • [22] Rab35 is a novel ciliary protein.
    Seixas, C.
    Ramalho, J.
    Barral, D.
    MOLECULAR BIOLOGY OF THE CELL, 2012, 23
  • [23] Rab GTPase function in Golgi trafficking
    Barr, Francis A.
    SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2009, 20 (07) : 780 - 783
  • [24] The small GTPase RAB35 coordinates epithelial polarization and cell survival in a human model of epiblast formation
    Rengarajan, A.
    Taniguchi, K.
    MOLECULAR BIOLOGY OF THE CELL, 2023, 34 (02) : 210 - 211
  • [25] Adaptations of membrane trafficking in cancer and tumorigenesis
    Evergren, Emma
    Mills, Ian G.
    Kennedy, Grace
    JOURNAL OF CELL SCIENCE, 2024, 137 (10)
  • [26] Rab35 GTPase recruits NDP52 to autophagy targets (vol 36, pg 2790, 2017)
    Minowa-Nozawa, Atsuko
    Nozawa, Takashi
    Okamoto-Furuta, Keiko
    Kohda, Haruyasu
    Nakagawa, Ichiro
    EMBO JOURNAL, 2017, 36 (22): : 3405 - 3405
  • [27] Rab35 Targeting to the Plasma Membrane Is Dependent on the C-terminal Polybasic Cluster
    Kawai, Katsuhisa
    Egami, Youhei
    Nishigaki, Arata
    Araki, Nobukazu
    ACTA HISTOCHEMICA ET CYTOCHEMICA, 2020, 53 (04) : 93 - 97
  • [28] Rab35/ACAP2和Rab35/RUSC2的复合物结构揭示小G蛋白Rab35识别效应蛋白的分子机制
    朱金伟
    张荣光
    林霖
    Yingdong Shi
    Mengli Wang
    Chao Wang
    科学新闻, 2020, (02) : 119 - 119
  • [29] Rab35 GTPase couples cell division with initiation of epithelial apico-basal polarity and lumen opening
    Klinkert, Kerstin
    Rocancourt, Murielle
    Houdusse, Anne
    Echard, Arnaud
    NATURE COMMUNICATIONS, 2016, 7
  • [30] Rab35 GTPase couples cell division with initiation of epithelial apico-basal polarity and lumen opening
    Kerstin Klinkert
    Murielle Rocancourt
    Anne Houdusse
    Arnaud Echard
    Nature Communications, 7
12345