Karyotype evolution and acquisition of FLT3 or RAS pathway alterations drive progression of myelodysplastic syndrome to acute myeloid leukemia

被引:30
|
作者
Meggendorfer, Manja [1 ]
de Albuquerque, Andreia [1 ]
Nadarajah, Niroshan [1 ]
Alpermann, Tamara [1 ]
Kern, Wolfgang [1 ]
Steuer, Kimberly [1 ]
Perglerova, Karolna [2 ]
Haferlach, Claudia [1 ]
Schnittger, Susanne [1 ]
Haferlach, Torsten [1 ]
机构
[1] MLL Munich Leukemia Lab, Munich, Germany
[2] MLL2 Sro, Prague, Czech Republic
关键词
MDS; s-AML; mutation analysis; MUTATIONS; FREQUENCY; PROGNOSIS; NPM1; NRAS; MDS;
D O I
10.3324/haematol.2015.127985
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:E487 / E490
页数:4
相关论文
共 50 条
  • [31] FLT3 Inhibitors in the Management of Acute Myeloid Leukemia
    Zappone, E.
    Defina, M.
    Aprile, L.
    Bartalucci, G.
    Gozzetti, A.
    Bocchia, M.
    ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2017, 17 (08) : 1028 - 1032
  • [32] Chromosomal alterations associated with evolution from myelodysplastic syndrome to acute myeloid leukemia
    Fernandez, TD
    Ornellas, MH
    de Carvalho, LO
    Tabak, D
    Abdelhay, E
    LEUKEMIA RESEARCH, 2000, 24 (10) : 839 - 848
  • [33] FLT3 mutations in myelodysplastic syndrome and chronic myelomonocytic leukemia
    Daver, Naval
    Strati, Paolo
    Jabbour, Elias
    Kadia, Tapan
    Luthra, Raja
    Wang, Sa
    Patel, Keyur
    Ravandi, Farhad
    Cortes, Jorge
    Dong, Xiao Qin
    Kantarjian, Hagop
    Garcia-Manero, Guillermo
    AMERICAN JOURNAL OF HEMATOLOGY, 2013, 88 (01) : 56 - 59
  • [34] FLT3 and NPM1 Mutations in Myelodysplastic Syndromes Frequency and Potential Value for Predicting Progression to Acute Myeloid Leukemia
    Bains, Ashish
    Luthra, Rajyalakshmi
    Medeiros, L. Jeffrey
    Zuo, Zhuang
    AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2011, 135 (01) : 62 - 69
  • [35] FLT3, RAS, and TP53 mutations in elderly patients with acute myeloid leukemia
    Stirewalt, DL
    Kopecky, KJ
    Meshinchi, S
    Appelbaum, FR
    Slovak, ML
    Willman, CL
    Radich, JP
    BLOOD, 2001, 97 (11) : 3589 - 3595
  • [36] Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia
    Kiyoi, H
    Naoe, T
    Nakano, Y
    Yokota, S
    Minami, S
    Miyawaki, S
    Asou, N
    Kuriyama, K
    Jinnai, I
    Shimazaki, C
    Akiyama, H
    Saito, K
    Oh, H
    Motoji, T
    Omoto, E
    Saito, H
    Ohno, R
    Ueda, R
    BLOOD, 1999, 93 (09) : 3074 - 3080
  • [37] Incorporating FLT3 inhibitors in the frontline treatment of FLT3 mutant acute myeloid leukemia
    Wang, Eunice S.
    BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY, 2019, 32 (02) : 154 - 162
  • [38] Dynamic acquisition of FLT3 or RAS alterations drive a subset of patients with lower risk MDS to secondary AML
    Takahashi, K.
    Jabbour, E.
    Wang, X.
    Luthra, R.
    Bueso-Ramos, C.
    Patel, K.
    Pierce, S.
    Yang, H.
    Wei, Y.
    Daver, N.
    Faderl, S.
    Ravandi, F.
    Estrov, Z.
    Cortes, J.
    Kantarjian, H.
    Garcia-Manero, G.
    LEUKEMIA, 2013, 27 (10) : 2081 - 2083
  • [39] Dynamic acquisition of FLT3 or RAS alterations drive a subset of patients with lower risk MDS to secondary AML
    K Takahashi
    E Jabbour
    X Wang
    R Luthra
    C Bueso-Ramos
    K Patel
    S Pierce
    H Yang
    Y Wei
    N Daver
    S Faderl
    F Ravandi
    Z Estrov
    J Cortes
    H Kantarjian
    G Garcia-Manero
    Leukemia, 2013, 27 : 2081 - 2083
  • [40] NPM1 and FLT3 mutations in acute myeloid leukemia with normal karyotype: Indian perspective
    Sazawal, Sudha
    Singh, Neha
    Jain, Sonal
    Chhikara, Sunita
    Chaubey, Rekha
    Bhattacharyya, Jina
    Saikia, Kandarpa Kr
    Mahapatra, Manoranjan
    Saxena, Renu
    INDIAN JOURNAL OF PATHOLOGY AND MICROBIOLOGY, 2017, 60 (03) : 355 - 359