Clinical assessment of fluorescence cystoscopy during transurethral bladder resection in superficial bladder cancer

被引：18
|
作者：
Jichlinski, P
Wagnieres, G
Forrer, M
Mizeret, J
Guillou, L
Oswald, M
Schmidlin, F
Graber, P
VandenBergh, V
Leisinger, HJ
机构：
[1] ECOLE POLYTECH FED LAUSANNE, SWISS FED INST TECHNOL, LAB ENVIRONM ENGN, CH-1015 LAUSANNE, SWITZERLAND
[2] CHU VAUDOIS, UNIV HOSP, INST PATHOL, CH-1011 LAUSANNE, SWITZERLAND
[3] UNIV HOSP GENEVA, HCUG, DEPT UROL, CH-1205 GENEVA, SWITZERLAND
来源：
UROLOGICAL RESEARCH | 1997年 / 25卷 / Suppl 1期
关键词：
carcinoma; transitional cell; cystoscopy; fluorescence; 5-aminolevulinic acid; protoporphyrin IX;
D O I：
10.1007/BF00942040
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
The prognosis of superficial bladder cancer in terms of recurrence and disease progression is related to bladder tumor multiplicity and the presence of concomitant ''plane'' tumors such as high-grade dysplasia and carcinoma in situ. This study in 33 patients aimed to demonstrate the role of fluorescence cystoscopy in transurethral resection of superficial bladder cancer. The method is based on the detection of protoporphyrin-IX-induced fluorescence in urothelial cancer cells by topical administration of 5-aminolevulinic acid. The sensitivity and the specificity of this procedure on apparently normal mucosa in superficial bladder cancer are estimated to be 82.9% and 81.3%, respectively. Thus, fluorescence cytoscopy is a simple and reliable method for mapping the bladder mucosa, especially in the case of multifocal bladder disease, and it facilitates the screening of occult dysplasia.
引用
收藏
页码：S3 / S6
页数：4
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