Molecular surface morphology studies of beta-amyloid self-assembly: Effect of pH on fibril formation

被引：0
|
作者：
Shivji, AP
Davies, MC
Roberts, CJ
Tendler, SJB
Wilkinson, MJ
机构：
[1] UNIV NOTTINGHAM,DEPT PHARMACEUT SCI,LAB BIOPHYS & SURFACE ANAL,NOTTINGHAM NG7 2RD,ENGLAND
[2] SMITHKLINE BEECHAM PHARMACEUT,DEPT ANALYT SCI,MICROSCOPY & FLOW CYTOMETRY,SURREY RH3 7AJ,ENGLAND
来源：
PROTEIN AND PEPTIDE LETTERS | 1996年 / 3卷 / 06期
关键词：
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Deposition of beta-amyloid fibrils within senile plaques in the brain is a major hallmark of Alzheimer's disease. In this study, atomic force microscopy (AFM) has been used to provide surface topographical data of beta-amyloid fibrillization as a function of pH. Alteration of pH has led to observed changes in fibril self-assembly rate, diameter and branching. These results suggest that pH has a profound affect on beta-amyloid self-assembly and surface morphology.
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页码：407 / 414
页数：8
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