Absence of an interaction between iron and mycophenolate mofetil absorption

Aim To determine whether concomitant iron affects the absorption of mycophenolate mofetil. Methods An open-label, single centre, randomized, crossover trial was conducted in 16 healthy males. Fasting subjects received mycophenolate mofetil alone (treatment A) or co-administered with iron (treatment B). Results The mycophenolic acid AUC(0,24 h) for treatments A and B were 42.5 +/- 10.5 and 44.7 +/- 12.4 mu g ml(-1) h, respectively. ANOVA modelling showed the relative bioavailability of mycophenolate mofetil to be similar for the two treatments (90% confidence interval 0.92, 1.19). Conclusions There was no interaction between mycophenolate mofetil and iron supplements administered concomitantly to healthy fasting subjects.