CircRNA hsa_circ_0004771 promotes esophageal squamous cell cancer progression via miR-339-5p/CDC25A axis

被引：57
|
作者：
Huang, Enmin [1 ]
Fu, Junhui [2 ]
Yu, Qiuyan [3 ]
Xie, Peixin [2 ]
Yang, Zhongxian [4 ]
Ji, Huanlin [3 ]
Wang, Li [3 ]
Luo, Ganfeng [3 ]
Zhang, Yanting [3 ]
Li, Ke [3 ]
机构：
[1] Shantou Univ, Dept Gen Surg, Affiliated Hosp 2, Med Coll, Shantou, Guangdong, Peoples R China
[2] Shantou Cent Hosp, Dept Surg Oncol, Shantou, Guangdong, Peoples R China
[3] Shantou Univ, Dept Publ Hlth, Med Coll, Shantou, Guangdong, Peoples R China
[4] Shantou Univ, Dept Med Imaging, Affiliated Hosp 2, Med Coll, Shantou, Guangdong, Peoples R China
来源：
EPIGENOMICS | 2020年 / 12卷 / 07期
基金：
中国国家自然科学基金;
关键词：
CDC25A; circRNA; differential expression; ESCC; hsa_circ_0004771; mechanism study; miR-339-5p; molecular sponge; RNA-Seq analysis; tumor biomarker; CIRCULAR RNA; TUMOR-SUPPRESSOR; CARCINOMA; MICRORNA; IDENTIFICATION; CDC25A; EXPRESSION; BIOMARKER; EFFICIENT; EXOSOMES;
D O I：
10.2217/epi-2019-0404
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Aim: The role of circRNAs in esophageal squamous cell cancer (ESCC) remains unclear. Materials & methods: Here we profiled six pair plasma circRNA in ESCC based on RNA sequencing, and then verified the elevation of hsa_circ_0004771 in 20 cancer tissues and 105 pair case-control plasma samples by quantitative reverse transcriptase PCR. Results: The upregulation of hsa_circ_0004771 was correlated with heavier tumor burden and poor prognosis, knockdown of it inhibited the ESCC cells proliferation both in vitro and in vivo. Mechanistically, hsa_circ_0004771 positively regulated CDC25A by acting as a molecular sponge of miR-339-5p and rescue assay confirmed this regulatory relationship. Conclusion: These results suggested that hsa_circ_0004771 can serve as a general less-invasive biomarker and may provide diagnostic and prognostic value in carcinoma.
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页码：587 / 603
页数：17
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