Palladium-catalyzed alkenation of thiophenes and furans by regioselective C-H bond functionalization

被引：42
|
作者：
Zhao, Jinlong [1 ]
Huang, Lehao [1 ]
Cheng, Kai [1 ]
Zhang, Yuhong [1 ]
机构：
[1] Zhejiang Univ, Dept Chem, Hangzhou 310027, Peoples R China
来源：
TETRAHEDRON LETTERS | 2009年 / 50卷 / 23期
关键词：
Palladium; Heterocycles; Thiophene; Alkenation; C-H activation; HECK REACTION; ARYL CHLORIDES; OLEFINATION; ARYLATION; ALKENYLATION; ACTIVATION; VINYLATION; ALDEHYDES; BENZENES; LIGANDS;
D O I：
10.1016/j.tetlet.2009.03.124
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A palladium-catalyzed direct alkenation of thiophenes and furans has been developed in the presence of AgOAc and pyridine. A variety of olefinic substrates such as acrylates, acrylamides, and acrylonitrile can perform the direct oxidative coupling reactions with various thiophenes and furans to give the mono-alkenylated products in good yields. In most cases, the (E)-isomers were isolated as the major products. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2758 / 2761
页数：4
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