Restoring function after spinal cord injury: towards clinical translation of experimental strategies

被引：245

作者：

Ramer, Leanne M. ^{[1
,2
]}

Ramer, Matt S. ^{[1
,2
,3
]}

Bradbury, Elizabeth J. ^{[1
]}

机构：

[1] Kings Coll London, Regenerat Grp, Wolfson Ctr Age Related Dis, London SE1 1UL, England

[2] Vancouver Gen Hosp, Blusson Spinal Cord Ctr, Int Collaborat Repair Discoveries, Vancouver, BC, Canada

[3] Univ British Columbia, Dept Zool, Vancouver, BC, Canada

来源：

LANCET NEUROLOGY | 2014年 / 13卷 / 12期

基金：

英国医学研究理事会; 加拿大健康研究院; 加拿大自然科学与工程研究理事会;

关键词：

CHONDROITIN SULFATE PROTEOGLYCAN; NOGO-66 RECEPTOR ANTAGONIST; RAT CORTICOSPINAL TRACT; DEEP BRAIN-STIMULATION; NEURAL STEM-CELLS; AXON REGENERATION; EPIDURAL STIMULATION; ADULT-RAT; LOCOMOTOR RECOVERY; LONG-TERM;

D O I：

10.1016/S1474-4422(14)70144-9

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Spinal cord injury is currently incurable and treatment is limited to minimising secondary complications and maximising residual function by rehabilitation. Improved understanding of the pathophysiology of spinal cord injury and the factors that prevent nerve and tissue repair has fuelled a move towards more ambitious experimental treatments aimed at promoting neuroprotection, axonal regeneration, and neuroplasticity. By necessity, these new options are more invasive. However, in view of recent advances in spinal cord injury research and demand from patients, clinicians, and the scientific community to push promising experimental treatments to the dinic, momentum and optimism exist for the translation of candidate experimental treatments to clinical spinal cord injury. The ability to rescue, reactivate, and rewire spinal systems to restore function after spinal cord injury might soon be within reach.

引用

页码：1241 / 1256

页数：16

共 50 条

[21] Alterations in immune cell phenotype and function after experimental spinal cord injury
Popovich, PG
Stuckman, S
Gienapp, IE
Whitacre, CC
JOURNAL OF NEUROTRAUMA, 2001, 18 (09) : 957 - 966
[22] ASTROCYTES IN SPINAL CORD INJURY: TOWARDS CLINICAL APPLICATION
Perrin, F.
GLIA, 2011, 59 : S15 - S15
[23] Experimental and Clinical Advances in Immunotherapy Strategies for Spinal Cord Injury Target on MAIs and Their Receptors
Lu, Xiu-Min
Wei, Jing-Xiang
Xiao, Lan
Shu, Ya-Hai
Wang, Yong-Tang
CURRENT PHARMACEUTICAL DESIGN, 2016, 22 (06) : 728 - 737
[24] Effect of injury severity on lower urinary tract function after experimental spinal cord injury
Wrathall, JR
Emch, GS
AUTONOMIC DYSFUNCTION AFTER SPINAL CORD INJURY, 2006, 152 : 117 - 134
[25] Adaptational strategies of persons after spinal cord injury
Tominc, M
INTERNATIONAL JOURNAL OF REHABILITATION RESEARCH, 2004, 27 : 159 - 160
[26] Experimental and clinical studies of eicosanoids in cerebrospinal fluid after spinal cord injury
Nishisho, T
Tonai, T
Tamura, Y
Ikata, T
NEUROSURGERY, 1996, 39 (05) : 950 - 956
[27] Spinal cord stimulation for the restoration of bladder function after spinal cord injury
Steadman, Casey J.
Grill, Warren M.
HEALTHCARE TECHNOLOGY LETTERS, 2020, 7 (03) : 87 - 92
[28] Manipulating the neuroimmune axis after spinal cord injury: Experimental and clinical considerations
Popovich, PG
FASEB JOURNAL, 2000, 14 (04): : A776 - A776
[29] Electrophysiological biomarkers of neuromodulatory strategies to recover motor function after spinal cord injury
Gad, Parag
Roy, Roland R.
Choe, Jaehoon
Creagmile, Jack
Zhong, Hui
Gerasimenko, Yury
Edgerton, V. Reggie
JOURNAL OF NEUROPHYSIOLOGY, 2015, 113 (09) : 3386 - 3396
[30] Deep brain stimulation could provide a new approach for restoring motor function after spinal cord injury
Nature Reviews Neurology, 2013, 9 (12) : 659 - 659

← 1 2 3 4 5 →