Marizomib for central nervous system-multiple myeloma

被引：62
|
作者：
Badros, Ashraf [1 ]
Singh, Zeba [1 ]
Dhakal, Binod [2 ]
Kwok, Young [1 ]
MacLaren, Ann [3 ]
Richardson, Paul [4 ]
Trikha, Mohit [3 ]
Hari, Parameswaran [2 ]
机构：
[1] Univ Maryland, Med Ctr, M&S Greenebaum Canc Ctr, Baltimore, MD 21201 USA
[2] Med Coll Wisconsin, Div Hematol Oncol, Milwaukee, WI 53226 USA
[3] Triphase Accelerator, San Diego, CA USA
[4] Dana Farber Canc Inst, Boston, MA 02115 USA
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2017年 / 177卷 / 02期
关键词：
multiple myeloma; central nervous system relapse; clinical studies; marizomib; INVOLVEMENT;
D O I：
10.1111/bjh.14498
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Marizomib, a natural marine product, is an irreversible proteasome inhibitor currently under investigation in relapsed-refractory multiple myeloma (RRMM) and malignant glioma. Central nervous system-multiple myeloma (CNS-MM) is a rare manifestation of extra-medullary disease with few therapeutic options, highlighting the unmet clinical need in these patients. Marizomib demonstrated encouraging activity in RRMM and has emerging clinical activity in glioma, making it a potential CNS-MM therapeutic intervention. Herein, we present two patients with RRMM and CNS involvement who benefited from marizomib-based therapy. Thesecases provide the first proof of principle for further exploring marizomib in CNS-MM patients.
引用
收藏
页码：221 / 225
页数：5
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