The targeting of non-coding RNAs by curcumin: Facts and hopes for cancer therapy

被引：45
|
作者：
Liu, Yun [1 ,2 ]
Sun, Hongmei [3 ]
Makabel, Bolat [4 ]
Cui, Qingbin [5 ,6 ]
Li, Jiajun [1 ,2 ]
Su, Chaoyue [1 ,2 ]
Ashby, Charles R., Jr. [5 ]
Chen, Zhesheng [5 ]
Zhang, Jianye [1 ,2 ]
机构：
[1] Guangzhou Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab Mol Target & Clin Pharmaco, Guangzhou 511436, Guangdong, Peoples R China
[2] Guangzhou Med Univ, Affiliated Hosp 5, Guangzhou 511436, Guangdong, Peoples R China
[3] Infinitus China Co Ltd, Jiangmen 529156, Guangdong, Peoples R China
[4] Xinjiang Inst Mat Med, Urumqi 830004, Xinjiang, Peoples R China
[5] St Johns Univ, Coll Pharm & Hlth Sci, 8000 Utopia Pkwy, New York, NY 11439 USA
[6] Guangzhou Med Univ, Coll Publ Hlth, Guangzhou 511436, Guangdong, Peoples R China
来源：
ONCOLOGY REPORTS | 2019年 / 42卷 / 01期
基金：
中国国家自然科学基金;
关键词：
curcumin; natural product; food; diet; miRNA; lncRNA; cancer; epigenetic pharmacology; INHIBITS CELL-GROWTH; BREAST-CANCER; PROSTATE-CANCER; COLORECTAL-CANCER; DOWN-REGULATION; UP-REGULATION; NASOPHARYNGEAL CARCINOMA; IN-VITRO; SECONDARY METABOLITES; MITOCHONDRIAL PATHWAY;
D O I：
10.3892/or.2019.7148
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Curcumin [(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl) hepta-1,6-diene-3,5-dione] is a natural polyphenol that is derived from the turmeric plant (curcuma longa L.). Curcumin is widely used in food coloring, preservatives, and condiments. Curcumin possesses anti-tumor, anti-oxidative and anti-inflammatory efficacy, as well as other pharmacological effects. Emerging evidence indicates that curcumin alters microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) in various types of cancers. Both miRNAs and lncRNAs are non-coding RNAs that can epigenetically modulate the expression of multiple genes via post-transcriptional regulation. In the present review, the interactions between curcumin and non-coding RNAs are summarized in numerous types of cancers, including lung, colorectal, prostate, breast, nasopharyngeal, pancreatic, blood, and ovarian cancer, and the vital non-coding RNAs and their downstream targets are described.
引用
收藏
页码：20 / 34
页数：15
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