Acute hepatitis induced by alpha-interferon, associated with viral clearance, in chronic hepatitis C

被引：12
|
作者：
Cervoni, JP
Degos, F
Marcellin, P
Erlinger, S
机构：
[1] HOP BEAUJON,SERV HEPATOL,F-92118 CLICHY,FRANCE
[2] HOP BEAUJON,INSERM U34,UNITE RECH PHYSIOPATHOL HEPAT,F-92118 CLICHY,FRANCE
来源：
JOURNAL OF HEPATOLOGY | 1997年 / 27卷 / 06期
关键词：
autoimmune hepatitis; hepatitis C virus; interferon;
D O I：
10.1016/S0168-8278(97)80157-2
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
We describe the cases of two patients with chronic hepatitis C who developed acute hepatitis with marked amino-transferase elevations and jaundice 3 and 5 months after initiation of interferon treatment. Hepatitis resolved rapidly after cessation of interferon. No autoantibodies were detected. Hepatitis was followed by viral clearance, demonstrated by clearance of hepatitis C viraemia. We propose that hepatitis may be due to an immune lysis of hepatocytes and suggest that this immune response may contribute to viral clearance.
引用
收藏
页码：1113 / 1116
页数：4
相关论文
共 50 条
  • [21] Parameters predicting response to alpha-interferon treatment in chronic hepatitis C
    Gluck, T
    Seelig, R
    Dette, S
    Buhring, HJ
    Renz, M
    Kwon, S
    Wiedmann, KH
    Weber, P
    [J]. HEPATO-GASTROENTEROLOGY, 1997, 44 (14) : 484 - 491
  • [22] IRON OVERLOAD AND RESPONSE TO ALPHA-INTERFERON IN CHRONIC HEPATITIS-C
    GIRELLI, CM
    MIRATA, C
    LESINIGO, E
    CASIRAGHI, A
    [J]. AMERICAN JOURNAL OF GASTROENTEROLOGY, 1995, 90 (01): : 170 - 171
  • [23] PREDICTING RESPONSE TO ALPHA-INTERFERON IN PATIENTS WITH CHRONIC HEPATITIS-C
    ALTMAN, C
    CASTEUR, A
    LAURENTPUIG, P
    BUFFET, C
    PELLETIER, G
    ETIENNE, JP
    DUSSAIX, E
    BEDOSSA, P
    [J]. EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 1994, 6 (01) : 71 - 71
  • [24] COMBINATION THERAPY WITH RIBAVIRIN AND ALPHA-INTERFERON IN PATIENTS WITH CHRONIC HEPATITIS-C RESISTANT TO ALPHA-INTERFERON TREATMENT
    BRILLANTI, S
    MASCI, C
    MIGLIOLI, M
    BARBARA, L
    [J]. HEPATOLOGY, 1993, 18 (04) : A150 - A150
  • [25] AUTOIMMUNITY DURING ALPHA-INTERFERON THERAPY FOR CHRONIC HEPATITIS-C
    YOSHIKAWA, M
    SAKAMOTO, T
    MITORO, A
    MOCHI, T
    TSUJII, H
    KOIZUMI, M
    YOSHIJI, H
    SAKAGUCHI, Y
    FUKUI, H
    NAKANO, H
    TSUJII, T
    [J]. GASTROENTEROLOGIA JAPONICA, 1993, 28 : 109 - 114
  • [26] CAN CHRONIC HEPATITIS-C BE HEALED BY ALPHA-INTERFERON THERAPY
    PAYEN, JL
    HALIMI, A
    VINEL, JP
    COMBIS, JM
    VOIGT, JJ
    PASCAL, JP
    [J]. HEPATOLOGY, 1993, 18 (04) : A249 - A249
  • [27] Association of alpha-interferon and acetyl cysteine in patients with chronic C hepatitis
    Neri, S
    Ierna, D
    Antoci, S
    Campanile, E
    D'Amico, RA
    Noto, R
    [J]. PANMINERVA MEDICA, 2000, 42 (03) : 187 - 192
  • [28] ACUTE-RENAL-FAILURE ASSOCIATED WITH ALPHA-INTERFERON THERAPY FOR CHRONIC HEPATITIS-B
    MIRANDAGUARDIOLA, F
    FDEZLLAMA, P
    BADIA, JR
    BOTEY, A
    ESTRUCH, R
    DARNELL, A
    ROZMAN, C
    REVERT, L
    [J]. NEPHROLOGY DIALYSIS TRANSPLANTATION, 1995, 10 (08) : 1441 - 1443
  • [29] ANTI-ALPHA INTERFERON ANTIBODIES AFTER ALPHA-INTERFERON TREATMENT IN PATIENTS WITH CHRONIC VIRAL-HEPATITIS
    CRAXI, A
    DIMARCO, V
    VOLPES, R
    PALAZZO, U
    [J]. HEPATO-GASTROENTEROLOGY, 1988, 35 (06) : 304 - 305
  • [30] IS THERE AN ALTERNATIVE TO ALPHA-INTERFERON IN CHRONIC HEPATITIS-B
    DEMOURA, MC
    VELOSA, J
    PINTO, HC
    [J]. JOURNAL OF HEPATOLOGY, 1991, 13 : S12 - S16
12345