Recombination in telomere-length maintenance

被引：80
|
作者：
Kass-Eisler, A
Greider, CW
机构：
[1] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA
[2] Johns Hopkins Univ, Sch Med, Dept Mol Biol & Genet, Baltimore, MD 21205 USA
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 2000年 / 25卷 / 04期
关键词：
D O I：
10.1016/S0968-0004(00)01557-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Although telomerase is the major mechanism for telomere elongation in most cells, telomerase-independent mechanisms of telomere maintenance can allow cell survival. Yeast cells that lack telomerase maintain telomere length through a form of recombination known as gene conversion. Understanding the role that telomeric recombination might play in mammalian cells has important implications for cancer therapeutics.
引用
收藏
页码：200 / 206
页数：9
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