Langerhans Cell Sarcoma: Case Report and Review of World Literature

被引：15

作者：

Zwerdling, Ted ^{[1
]}

Won, Eric ^{[2
]}

Shane, Lisa ^{[1
]}

Javahara, Ramin ^{[1
]}

Jaffe, Ronald ^{[3
]}

机构：

[1] Miller Childrens Hosp, Long Beach, CA 90806 USA

[2] Univ Calif Irvine, Dept Pediat, Irvine, CA 92717 USA

[3] UPMC, Childrens Hosp Pittsburgh, Pittsburgh, PA USA

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2014年 / 36卷 / 06期

关键词：

Langerhans cell sarcoma; pediatric; treatment; world review; COMMON CLONAL ORIGIN; OF-THE-LITERATURE; HISTIOCYTOSIS; LEUKEMIA; PATIENT; THERAPY; TUMOR;

D O I：

10.1097/MPH.0000000000000196

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Langerhans cell sarcoma is a rare malignancy with only 1 pediatric case (less than 15 y of age) reported. Here, we report the second case of Langerhans cell sarcoma in a child who presented with cord compression. This patient was treated with extensive surgical resection, postoperative chemotherapy, and involved-field radiation therapy. She completed therapy and remains in remission for 27 months. A review and analysis of all 53 cases published in the world literature is provided to help guide physicians treating this disease. Recently discovered genetic mutation involving BRAF is also discussed.

引用

页码：419 / 425

页数：7

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