A concise synthesis of nornitidine via nickel- or palladium-catalyzed annulation

被引：22
|
作者：
Luo, Yu
Mei, Yuhua
Zhang, Jianbo
Lu, Wei [1 ]
Tang, Jie
机构：
[1] E China Normal Univ, Inst Med Chem, Shanghai Key Lab Green Chem & Chem Proc, Dept Chem, Shanghai 200062, Peoples R China
[2] Chinese Acad Sci, SIBS, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
来源：
TETRAHEDRON | 2006年 / 62卷 / 39期
基金：
中国国家自然科学基金;
关键词：
benzo[c]phenanthridine; isoquinolines; nitidine; palladium; nickel; catalysis;
D O I：
10.1016/j.tet.2006.07.048
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A concise method to synthesize benzo[c]phenanthridine alkaloid, nornitidine, was developed utilizing nickel- or palladium-catalyzed iminoannulation of an internal alkyne. The advantages of this strategy included readily available starting materials, inexpensive reagents, short reaction steps, and good yields. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：9131 / 9134
页数：4
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