Copper-Catalyzed One-Pot Synthesis of N-Aryl Oxazolidinones from Amino Alcohol Carbamates

被引：34

作者：

Mahy, William ^{[1
]}

Plucinski, Pawel K. ^{[1
]}

Frost, Christopher G. ^{[1
]}

机构：

[1] Univ Bath, Dept Chem, Ctr Sustainable Chem Technol, Bath BA2 7AY, Avon, England

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 19期

基金：

英国工程与自然科学研究理事会;

关键词：

REVERSIBLE MONOAMINE-OXIDASE; COUPLING REACTIONS; HIGHLY EFFICIENT; BOND FORMATION; IODIDES; 2-OXAZOLIDINONES; ANTIBACTERIALS; DERIVATIVES; ARYLATION; BROMIDES;

D O I：

10.1021/ol502322c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient sequential intramolecular cyclization of amino alcohol carbamates followed by Cu-catalyzed cross-coupling with aryl iodides under mild conditions has been developed. The reaction occurred in good yields and tolerated aryl iodides containing functionalities such as nitriles, ketones, ethers, and halogens. Heteroaryl iodides and substituted amino alcohol carbamates were also well tolerated.

引用

页码：5020 / 5023

页数：4

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