Multitasking guardian of mitochondrial quality: Parkin function and Parkinson's disease

被引：44
|
作者：
Kamienieva, Iryna [1 ]
Duszynski, Jerzy [1 ]
Szczepanowska, Joanna [1 ]
机构：
[1] Polish Acad Sci, Nencki Inst Expt Biol, PL-02093 Warsaw, Poland
来源：
TRANSLATIONAL NEURODEGENERATION | 2021年 / 10卷 / 01期
基金：
欧盟地平线“2020”;
关键词：
Mitochondria; Parkinson's disease; Parkin; PINK1; Mitophagy; Parkin mutations; DOPAMINERGIC NEURON DEGENERATION; DAMAGED MITOCHONDRIA; SKIN FIBROBLASTS; PINK1-DEPENDENT PHOSPHORYLATION; ASYMPTOMATIC CARRIERS; DROSOPHILA MODEL; UBIQUITIN CHAIN; S-NITROSYLATION; REQUIRES PINK1; DEFICIENT MICE;
D O I：
10.1186/s40035-020-00229-8
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The familial form of Parkinson's disease (PD) is linked to mutations in specific genes. The mutations in parkin are one of the most common causes of early-onset PD. Mitochondrial dysfunction is an emerging active player in the pathology of neurodegenerative diseases, because mitochondria are highly dynamic structures integrated with many cellular functions. Herein, we overview and discuss the role of the parkin protein product, Parkin E3 ubiquitin ligase, in the cellular processes related to mitochondrial function, and how parkin mutations can result in pathology in vitro and in vivo.
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页数：18
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