Influence of various factors on alginate beads formation and mathematical modeling of drug release from beads

被引：0
|
作者：
Manaenkov, OV [1 ]
Sidorov, AI [1 ]
Klinger, AV [1 ]
Sulman, EA [1 ]
Klinger, EA [1 ]
Tichonov, BB [1 ]
机构：
[1] Tver State Tech Univ, Dept Biotechnol & Chem, Tver, Russia
来源：
MINERVA BIOTECNOLOGICA | 2005年 / 17卷 / 04期
关键词：
alginate beads; drug release; mathematical modeling;
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
In this work the influence of various physical and chemical factors on the process of calcium alginate beads structure formation was investigated. The greatest effect on this process was obtained with the use of ultrasonic treatment of an initial solution of sodium alginate. The mathematical modeling of drug release from beads has been carried out. The results of this work allow to receive drug delivery systems with the specified properties and to predict their behavior in the stomach conditions.
引用
收藏
页码：251 / 257
页数：7
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