Automatic reactor for solid-phase synthesis of molecularly imprinted polymeric nanoparticles (MIP NPs) in water

被引：86
|
作者：
Poma, Alessandro [1 ]
Guerreiro, Antonio [2 ]
Caygill, Sarah [2 ]
Moczko, Ewa [2 ]
Piletsky, Sergey [2 ]
机构：
[1] Open Univ, Dept Life Hlth & Chem Sci, Milton Keynes MK7 6AA, Bucks, England
[2] Univ Leicester, Dept Chem, Coll Sci & Engn, Leicester LE1 7RH, Leics, England
来源：
RSC ADVANCES | 2014年 / 4卷 / 08期
基金：
英国惠康基金;
关键词：
ANTIBODIES; NANOMEDICINE; IMMUNOASSAYS; STABILITY;
D O I：
10.1039/c3ra46838k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We report the development of an automated chemical reactor for solid-phase synthesis of MIP NPs in water. Operational parameters are under computer control, requiring minimal operator intervention. In this study, "ready for use" MIP NPs with sub-nanomolar affinity are prepared against pepsin A, trypsin and a-amylase in only 4 hours.
引用
收藏
页码：4203 / 4206
页数：4
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