Virtual Single-Source Computed Tomography Using Dual-Source Acquisition A New Technique for the Dose-Neutral Intraindividual Comparison of Different Scan Protocols

Objectives: The objective of this study was to compare the image quality of a standard single-source (SSS) computed tomography (CT) with that of a virtual single-source CT (VSS-CT) data set reconstructed from 2 raw data sets obtained by dual-source CT acquisition in abdominal CT to establish a radiation dose-neutral approach for the intraindividual comparison of 3 acquisition protocols at different radiation dose levels (RDLs). Materials and Methods: An abdominal phantom representing an 80-kg male was imaged using dual-source CT (SOMATOM Definition; Siemens Healthcare) at 3 RDLs with 120 kV(p) and different tube currents (low, standard, and high milliampere-second protocol). For each RDL, raw data were obtained once in single-source mode using x-ray tube A only and 5 times in dual-source mode using different ratios for tube current of x-ray tubes A and B (same total radiation dose; A/B: 90%/10%, 80%/20%, 70%/30%, 60%/40%, 50%/50%). For each RDL, SSS-CT and 5 virtual single-source image data sets (VSS-CT50-90) were reconstructed. To compare SSS-CT and VSS-CT data sets, image quality was assessed in terms of high- and low-contrast performance by calculating the modulation transfer function, image noise, noise power spectrum, and, for low contrast lesion detectability, the modified multiscale structural similarity index (MS-SSIM*). A maximum decrease of Delta = 5% of image quality compared with SSS-CT was defined as acceptable, and a noninferiority analysis with Delta was performed. Results: For modulation transfer function, noninferiority was observed for all VSS-CT data sets and RDL (P < 0.05). Image noise demonstrated an acceptable increase (<3.2%, P < 0.05) for each RDL and noise power spectrum showed only minor differences in the midfrequency range. The MS-SSIM* index demonstrated for the high RDL protocol a minor decrease for VSS-CT data sets (<2%, P < 0.05). For the standard and low RDL, the relative differences of the MS-SSIM* index increased and were only in 1 case above Delta (standard RDL, mean VSS-CT80 5.1%, P > 0.05). Conclusions: The image quality obtained by virtual and SSS reconstruction using equivalent total radiation exposure to the patient showed only negligible differences in image quality. Therefore, this technique might allow an intraindividual comparison of full and reduced radiation dose protocols within 1 image acquisition step by simply splitting the radiation dose between the 2 x-ray tubes of a dual-source CT.