Marine Bioactive Compounds against Aspergillus fumigatus: Challenges and Future Prospects

被引：4

作者：

Ahamefule, Chukwuemeka Samson ^{[1
,2
,3
]}

Ezeuduji, Blessing C. ^{[4
]}

Ogbonna, James C. ^{[3
]}

Moneke, Anene N. ^{[3
]}

Ike, Anthony C. ^{[3
]}

Wang, Bin ^{[1
,5
]}

Jin, Cheng ^{[1
,2
]}

Fang, Wenxia ^{[1
,5
]}

机构：

[1] Guangxi Acad Sci, Natl Engn Res Ctr Nonfood Biorefinery, Nanning 530007, Peoples R China

[2] Guangxi Univ, Coll Life Sci & Technol, Nanning 530005, Peoples R China

[3] Univ Nigeria, Dept Microbiol, Nsukka 410001, Nigeria

[4] Univ Jos, Dept Microbiol, Jos 930001, Nigeria

[5] Guangxi Acad Sci, State Key Lab Nonfood Biomass & Enzyme Technol, Nanning 530007, Peoples R China

来源：

ANTIBIOTICS-BASEL | 2020年 / 9卷 / 11期

基金：

中国国家自然科学基金;

关键词：

marine resources; Aspergillus fumigatus; bioactive compounds; screening model; fungi; TRITERPENE GLYCOSIDES; SEA-CUCUMBER; IMMUNOCOMPETENT PATIENTS; ANTIFUNGAL ACTIVITY; CRANIOCEREBRAL ASPERGILLOSIS; ORBITAL ASPERGILLOSIS; BIOFILM FORMATION; SINONASAL ORIGIN; RED ALGAE; RESISTANCE;

D O I：

10.3390/antibiotics9110813

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

With the mortality rate of invasive aspergillosis caused by Aspergillus fumigatus reaching almost 100% among some groups of patients, and with the rapidly increasing resistance of A. fumigatus to available antifungal drugs, new antifungal agents have never been more desirable than now. Numerous bioactive compounds were isolated and characterized from marine resources. However, only a few exhibited a potent activity against A. fumigatus when compared to the multitude that did against some other pathogens. Here, we review the marine bioactive compounds that display a bioactivity against A. fumigatus. The challenges hampering the discovery of antifungal agents from this rich habitat are also critically analyzed. Further, we propose strategies that could speed up an efficient discovery and broaden the dimensions of screening in order to obtain promising in vivo antifungal agents with new modes of action.

引用

页码：1 / 19

页数：19

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