Ruthenium(II) Complexes Containing Anti-Inflammatory Drugs as Ligands: Synthesis, Characterization and in vitro Cytotoxicity Activities on Cancer Cell Lines

被引：22
|
作者：
Lopes, Junai C. S. [1 ,2 ]
Damasceno, Jaqueline L. [3 ]
Oliveira, Pollyanna F. [3 ]
Guedes, AdrianaP. M. [4 ]
Tavares, Denise C. [3 ]
Deflon, Victor M. [5 ]
Lopes, Norberto P. [6 ]
Pivatto, Marcos [2 ]
Batista, Alzir A. [4 ]
Maia, Pedro I. S. [7 ]
Von Poelhsitz, Gustavo [2 ]
机构：
[1] Inst Fed Norte Minas Gerais, BR-39270000 Pirapora, MG, Brazil
[2] Univ Fed Uberlandia, Dept Quim, BR-38400902 Uberlandia, MG, Brazil
[3] Univ Franca, BR-14404600 Franca, SP, Brazil
[4] Univ Fed Sao Carlos, Dept Quim, BR-13561901 Sao Carlos, SP, Brazil
[5] Univ Fed Sao Carlos, Inst Quim Sao Carlos, BR-13566590 Sao Carlos, SP, Brazil
[6] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, NPPNS, BR-14040903 Ribeirao Preto, SP, Brazil
[7] Univ Fed Triangulo Mineiro, Inst Ciencias Nat Exatas & Educ, BR-38064200 Uberaba, MG, Brazil
来源：
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | 2015年 / 26卷 / 09期
基金：
巴西圣保罗研究基金会;
关键词：
ruthenium(II) complexes; cytotoxic activity; sodium diclofenac; sodium ibuprofen; dppm; ANTICANCER AGENT; DNA; ELECTROCHEMISTRY; MONONUCLEAR; DICLOFENAC; CISPLATIN; THERAPY; BINDING; KP1019;
D O I：
10.5935/0103-5053.20150161
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The synthesis, characterization and cytotoxic activity of cis-[Ru(dicl)(dppm)(2)]PF6 and cis-[Ru(ibu)(dppm)(2)]PF6, (dppm = 1,1-bis(diphenylphosphine)methane; dicl = diclofenac anion and ibu = ibuprofen anion), are described in this work. Complexes were characterized by elemental analysis, Fourier transform infrared spectroscopy (FTIR), UV-Vis, P-31{H-1} nuclear magnetic resonance (NMR) and high-resolution mass spectrometry (HRESIMS). X-ray structure of cis-[Ru(ibu)(dppm)(2)]PF6 is also described. Preliminary calf thymus DNA (ct-DNA) binding studies were carried out by UV-Vis and viscosity experiments, with results suggesting the existence of electrostatic interactions between ruthenium complexes and ct-DNA. Cytotoxicity assays were carried out on a panel of human cancer cell lines and a human normal cell line. Complexes displayed a high to moderate cytotoxicity with IC50 ranging from 5 to 47 mu mol L-1. cis-[Ru(ibu) (dppm)(2)]PF6 was found to be the most active, with IC50 values lower than cisplatin. The degree of cytotoxicity was maintained for the normal cell line, although cis-[Ru(ibu)(dppm)(2)]PF6 exhibited a similar selectivity to that of cisplatin but with a higher activity for at least two tumor cell lines which evidences a promising anticancer candidate and selects this complex for further experiments.
引用
收藏
页码：1838 / 1847
页数：10
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