Ruthenium(II)/4,6-dimethyl-2-mercaptopyrimidine complexes: Synthesis, characterization, X-ray structures and in vitro cytotoxicity activities on cancer cell lines

被引：26
|
作者：
Mondelli, Melina A. [1 ]
Graminha, Angelica E. [1 ]
Correa, Rodrigo S. [1 ]
da Silva, Monize M. [1 ]
Carnizello, Andrea P. [1 ]
Von Poelhsitz, Gustavo [2 ]
Ellena, Javier [3 ]
Deflon, Victor M. [4 ]
Caramori, Giovanni F. [5 ]
Torre, Maria H. [6 ]
Tavares, Denise C. [7 ]
Batista, Alzir A. [1 ]
机构：
[1] Univ Fed Sao Carlos, Dept Quim, BR-13565905 Sao Carlos, SP, Brazil
[2] Univ Fed Uberlandia, Inst Quim, BR-38400902 Uberlandia, MG, Brazil
[3] Univ Sao Paulo, Inst Fis Sao Carlos, BR-13560970 Sao Carlos, SP, Brazil
[4] Univ Sao Paulo, Inst Quim Sao Carlos, BR-13566590 Sao Carlos, SP, Brazil
[5] Univ Fed Santa Catarina, Dept Quim CFM, BR-88040900 Florianopolis, SC, Brazil
[6] Univ La Republ, Fac Quim, Dept Estrella Campos, Catedra Quim Inorgan, Montevideo, Uruguay
[7] Univ Franca, BR-14404600 Franca, SP, Brazil
来源：
POLYHEDRON | 2014年 / 68卷
基金：
巴西圣保罗研究基金会;
关键词：
Ruthenium(II); Nitrosyl; Cytotoxicity; Crystal structure; dppb; 4,6-Dimethyl-2-mercaptopyrimidine; RUTHENIUM COMPLEXES; NITROSYL COMPLEXES; PLATINUM; LIGAND; DRUGS; REACTIVITY; SPYMME(2); TOXICITY; DESIGN;
D O I：
10.1016/j.poly.2013.11.001
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The complexes [RuCl(SpymMe(2)-N,S)(2)(NO)] (1) and [Ru(dppb)(SpymMe(2)-N,S)(2)] (2) (dppb = 1,4-bis(diphenylphosphino)butane, SpymMe(2) = deprotonated 4,6-dimethyl-2-mercaptopyrimidine) were obtained and characterized by elemental analysis, spectroscopic techniques including X-ray crystallography, conductimetry and cyclic voltammetry. Energy Decomposition Analysis (EDA) calculation indicated strong intermolecular interaction between monomers of complex I, as suggested by the H-1 NMR spectrum of this complex, in chloroform solution. Additionally, preliminary tests were carried out, in order to evaluate the cytotoxicity activity on cancer cell lines of the new complexes, and the free ligands, against MDA-MB-231 (breast cancer), Hela (cervical cancer), U251 (glioma cancer) tumor cell lines and the V79 (Chinese lung fibroblast hamster) cell line. The best result was obtained for the complex 1 with IC50 value of 0.11 +/- 0.02, against MDA-MB-231 tumor cells. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：312 / 318
页数：7
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