Expression of the myeloperoxidase gene in AC133 positive leukemia cells relates to the prognosis of acute myeloid leukemia

被引：10

作者：

Taguchi, Jun

Miyazaki, Yasushi

Tsutsumi, Chizuko

Sawayama, Yasushi

Ando, Koji

Tsushima, Hideki

Fukushima, Takuya

Hata, Tomoko

Yoshida, Shinichiro

Kuriyama, Kazutaka

Honda, Surnihisa

Jinnai, Itsuro

Mano, Hiroyuki

Tomonaga, Masao

机构：

[1] Nagasaki Univ, Grad Sch Biomed Sci, Atom Bomb Dis Inst, Dept Hematol, Nagasaki 8528523, Japan

[2] Nagasaki Univ, Grad Sch Biomed Sci, Atom Bomb Dis Inst, Mol Med Unit, Nagasaki 8528523, Japan

[3] Nagasaki Natl Med Ctr, Dept Internal Med, Nagasaki 8568562, Japan

[4] Univ Ryukyus, Sch Hlth Sci, Nishihara, Okinawa 9030215, Japan

[5] Nagasaki Univ, Grad Sch Biomed Sci, Atom Bomb Dis Inst, Dept Radiat Epidemiol, Nagasaki 8528523, Japan

[6] Jichi Med Sch, Div Funct Genom, Yakushiji, Tochigi 3290498, Japan

来源：

LEUKEMIA RESEARCH | 2006年 / 30卷 / 09期

关键词：

myeloperoxidase; gene expression; AC133; acute myeloid leukemia; prognostic factor;

D O I：

10.1016/j.leukres.2005.12.012

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We previously reported that the percentage of myeloperoxidase (MPO) positive blasts had a prognostic impact on survival of patients with acute myeloid leukemia (AML). To extend this observation, we quantitatively measured the level of the MPO gene in AC133 positive leukemia cells that would contain a putative AML stem/progenitor compartment. AML cases were divided into the MPO gene high (MPOg-H) and MPO gene low (MPOg-L) groups. Only patients belonging to the MPOg-H group had a favorable chromosomal translocation, t(8;21), and having no morphological dysplasia that was associated with MPOg-L. The difference in the survival of MPOg-H and MPOg-L was statistically meaningful, demonstrating the possible prognostic impact of the expression of MPO gene in AC133 positive leukemia cells. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：1105 / 1112

页数：8

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