Efficient siRNA-peptide conjugation for specific targeted delivery into tumor cells

被引：15

作者：

Gandioso, Albert ^{[1
]}

Massaguer, Anna ^{[2
]}

Villegas, Nuria ^{[3
,4
]}

Salvans, Candida ^{[3
]}

Sanchez, Dani ^{[3
]}

Brun-Heath, Isabelle ^{[3
]}

Marchan, Vicente ^{[1
]}

Orozco, Modesto ^{[3
,4
,5
]}

Terrazas, Montserrat ^{[3
]}

机构：

[1] Univ Barcelona, IBUB, Dept Inorgan & Organ Chem, Sect Organ Chem, Marti & Franques 1-11, E-08028 Barcelona, Spain

[2] Univ Girona, Dept Biol, Campus Montilivi, Girona 17071, Spain

[3] IRB Barcelona, Barcelona Inst Sci & Technol, Joint IRB BSC Program Computat Biol, Baldiri Reixac 10-12, Barcelona 08028, Spain

[4] IRB Barcelona, Join IRB BSC Program Computat Biol, Barcelona, Spain

[5] Univ Barcelona, Dept Biochem & Biomed, E-08028 Barcelona, Spain

来源：

CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 19期

基金：

欧洲研究理事会;

关键词：

CLICK CHEMISTRY; BREAST-CANCER; IN-VIVO; RNA; OLIGONUCLEOTIDES; POTENT; INTERFERENCE; SOMATOSTATIN; INHIBITION; STRATEGIES;

D O I：

10.1039/c6cc10287e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Despite the broad applicability of the Huisgen cycloaddition reaction, the click functionalization of RNAs with peptides still remains a challenge. Here we describe a straightforward method for the click functionalization of siRNAs with peptides of different sizes and complexities. Among them, a promising peptide carrier for the selective siRNA delivery into HER2+ breast cancer cell lines has been reported.

引用

页码：2870 / 2873

页数：4

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