Ovarian transcriptome associated with reproductive senescence in the long-living Ames dwarf mice

被引：23
|
作者：
Schneider, Augusto [1 ,2 ]
Matkovich, Scot J. [3 ]
Saccon, Tatiana [1 ]
Victoria, Berta [2 ]
Spinel, Lina [2 ]
Lavasani, Mitra [4 ,5 ]
Bartke, Andrzej [6 ,7 ]
Golusinski, Pawel [2 ,8 ,9 ]
Masternak, Michal M. [2 ,9 ]
机构：
[1] Univ Fed Pelotas, Fac Nutr, Rua Gomes Carneiro,1 Sala 239, BR-96020220 Pelotas, RS, Brazil
[2] Univ Cent Florida, Burnett Sch Biomed Sci, Coll Med, 6900 Lake Nona Blvd, Orlando, FL 32827 USA
[3] Washington Univ, Sch Med, Dept Med, Ctr Pharmacogen, St Louis, MO 63110 USA
[4] Rehabil Inst Chicago, Chicago, IL 60611 USA
[5] Northwestern Univ, Dept Phys Med & Rehabil, Feinberg Sch Med, Chicago, IL 60611 USA
[6] Southern Illinois Univ, Dept Internal Med, Sch Med, Springfield, IL USA
[7] Southern Illinois Univ, Dept Physiol, Sch Med, Springfield, IL USA
[8] Poznan Univ Med Sci, Dept Biol & Environm Studies, Poznan, Poland
[9] Greater Poland Canc Ctr, Dept Head & Neck Surg, Poznan, Poland
来源：
MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2017年 / 439卷 / 0C期
基金：
美国国家卫生研究院;
关键词：
Ovarian aging; GH; IGF; mRNA; Transcriptome; PRIMORDIAL FOLLICLE ACTIVATION; GENE-EXPRESSION; CALORIE RESTRICTION; LIFE-SPAN; GROWTH; INSULIN; CELLS; LONGEVITY; INITIATION; INDUCTION;
D O I：
10.1016/j.mce.2016.09.019
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The aim of the current work was to evaluate the ovarian follicle reserve and the ovarian transcriptome in Ames dwarf (df/df) mice. The results suggest a delayed ovarian aging in df/df mice compared to normal (N) mice. Although a high number of genes were differentially expressed during aging of N mice, only a small fraction of these changed with aging in df/df mice. These alterations involved more than 500 categorized biological processes. The majority of these biological processes, including inflammatory/immune responses, were up-regulated with aging in N mice, while old df/df mice were characterized by down-regulation of these same processes in comparison to age matched N mice. However, biological processes related to DNA damage and repairing were commonly down-regulated with aging in both genotypes. In conclusion, delayed ovarian aging in long-living df/df mice was associated with reduced expression of genes related to the inflammatory and immune responses. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：328 / 336
页数：9
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