The establishment of a segmental pattern within the vertebrate body plan is achieved during embryogenesis by the somitogenesis process. Two molecular systems have been implicated in this phenomenon: a molecular clock linked to vertebrate segmentation and the Notch signalling pathway. Rhythmic expression of the Lunatic Fringe gene in the presomitic mesoderm has now provided a link between these two systems.
机构:
Wiley VCH Verlag GmbH & Co KGaA, European Journal Organ Chem, D-69469 Weinheim, GermanyWiley VCH Verlag GmbH & Co KGaA, European Journal Organ Chem, D-69469 Weinheim, Germany